| Cat. No. |
Product Name |
Information |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-25360 |
CDK2 degrader 37
CDK2 PROTAC
|
CDK2 degrader 37 is a potent, orally bioavailable and selective degrader of CDK2 with DC50 of 17 nM in CCNE1nonamp TOV21G cell line, >100-fold selectivity over CDK1, and >500-fold selectivity over CDK9. |
| PC-25336 |
ABT-002
GSPT1/NEK7 degrader
|
ABT-002 is the active metabolite of ABS-752, a potent molecular glue degrader of GSPT1 and NEK7, impairs the viability of HCC cell lines. |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25327 |
JWJ-01-334
ZBTB11 degrader
|
JWJ-01-334 is a negative control compound of JWJ-01-306. |
| PC-25326 |
JWJ-01-368
ZBTB11 degrader
|
JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation. |
| PC-25325 |
JWJ-01-306
ZBTB11 degrader
|
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells. |
| PC-25306 |
LYA914
AR PROTAC
|
LYA914 is a potent, specific PROTAC degrader targeting the conserved DNA binding domain (DBD) of androgen receptor (AR) with DC50 of 0.45 uM and 0.34 uM for AR and AR-V7 in 22Rv1 cells, respectively. |
| PC-25289 |
TBK1 degrader 30
TBK1 degrader
|
TBK1 degrader 30 is a potent, selective TBK1 molecular glue degrader with DC50 of 360.5 and 350.8 nM, and Dmax values of 71.9 and 91.9% in A549 and 293T cells, respectively, induces TBK1 degradation in a dose-, time-, ubiquitin-proteasome system-, and RNF126-dependent manner. |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-25287 |
HaloPROTAC-E
Halo PROTAC
|
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with DC50 of 3-10 nM, significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy. |
