| Cat. No. |
Product Name |
Information |
| PC-20885 |
JET-209
CBP/p300 PROTAC
|
JET-209 (JET209) is a potent, selective PROTAC degrader of CBP/p300 based on GNE-207 with DC50 of 0.05 nM for CBP and 0.2 nM for p300, Dmax >95% for both proteins in the RS4;11 leukemia cell line. |
| PC-20816 |
PTD10
BTK PROTAC
|
PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853. |
| PC-20755 |
(R)-SL18
ANXA3 degrader
|
(R)-SL18 is a first-in-class, selective Annexin A3 (ANXA3) degrader, induces degradation of ANXA3 in MDA-MB-231 cells with DC50 value of 3.17 uM. |
| PC-20694 |
FHD-609
BRD9 PROTAC
|
FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex. |
| PC-20693 |
KT-474
IRAK4 PROTAC
|
KT-474 (SAR444656, KT474) is a potent, highly selective, orally bioavailable IRAK4 degrader for the treatment of IL-1R/TLR-driven conditions and diseases. |
| PC-20680 |
MRT-2359
GSPT1 PROTAC
|
MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%). |
| PC-20653 |
DeFer-2
Ferritin PROTAC
|
DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis. |
| PC-20593 |
CFT1946
mutant BRAF PROTAC
|
CFT1946 (CFT-1946) is a potent, selective CRBN-based PROTAC degrader of mutant BRAF, selectively degrades BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations and the p61-BRAFV600E splice variant, but not WT BRAF and CRAF. |
| PC-20565 |
CP5V
Cdc20 PROTAC
|
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation. |
| PC-20464 |
BI 1810284
SMARCA2 PROTAC
|
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4. |
| PC-20349 |
DU-14
PTP1B TC-PTP degrader
|
DU-14 is a highly potent and selective small molecule degrader for both PTP1B and TC-PTP with DC50 values of 4.3 and 4.8 nM, respectively, in HEK293 cells after 16 hours treatment. |
| PC-20323 |
LL-K8-22
CDK8 degarder
|
LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins. |
