| Cat. No. |
Product Name |
Information |
| PC-49380 |
INY-06-061
ERK5 PROTAC
|
INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment). |
| PC-49367 |
dBRD4-BD1
BRD4 degrader
|
dBRD4-BD1 is a potent, selective degrader of BRD4 with DC50 of 280 nM, Dmax 77%. |
| PC-49208 |
MS159
NSD2 PROTAC
|
MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1. |
| PC-49144 |
SJ1008030
JAK2 PROTAC
|
SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC. |
| PC-49143 |
SJ988497
JAKs PROTAC
|
SJ988497 is a highly potent JAKs degarder proteolysis-targeting chimera (PROTAC), potently kills CRLF2r ALL cell lines (MHH-CALL-4, IC50=0.4 nM). |
| PC-49082 |
HJM-561
EGFR C797S degarder
|
HJM-561 is a potent, selective and orally bioavailable EGFR PROTAC degrader, selectively degrades the EGFR C797S-containing triple mutants Del19/T790M/C797S and L858R/T790M/C797S with DC50 values of 9.2 nM and 5.8 nM, respectively. |
| PC-49078 |
YM281
EZH2 PROTAC
|
YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells. |
| PC-49077 |
MS8815
EZH2 PROTAC
|
MS8815 is a potent, selective EZH2 PROTAC degrader with IC50 of 8.6 nM against EZH2, induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells. |
| PC-49061 |
WDR5 PROTAC MS40
WDR5 degarder
|
WDR5 PROTAC MS40 is a cereblon (CRBN)-recruiting proteolysis targeting chimera (PROTAC) of WDR5, selectively degrades WDR5 and the Ikaros zinc finger (IKZF) transcription factors IKZF1 and IKZF3. |
| PC-49057 |
CDK2 degrader CPS2
CDK2 degrader
|
CDK2 degrader CPS2 is a potent, selective CDK2 degarder (PROTAC) with IC50 of 24 nM, potently and specifically induces CDK2 degradation in various cancer cell lines (MDA-MB-231, DC50=8 nM; MV-4-11, DC50=1 nM). |
| PC-49045 |
MD-224
MDM2 PROTAC
|
MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. |
| PC-49044 |
ARD-69
AR degarder
|
ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively. |
