| Cat. No. |
Product Name |
Information |
| PC-23963 |
DEG-77
IKZF2/CK1α degarder
|
DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively. |
| PC-23962 |
CC-91633
CK1α PROTAC
|
CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α). |
| PC-23961 |
DEG-35
IKZF2/CK1α degarder
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
| PC-23947 |
AN5777
GSPT1 degrader
|
AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS. |
| PC-23946 |
LYG-409
GSPT1 degrader
|
LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells. |
| PC-23910 |
QZ2135
RET PROTAC
|
QZ2135 is a potent, selective RET PROTAC degrader, effectively degrades RET kinase (DC50=4.7 nM) and its resistant mutants, such as V804M (DC50=17.2 nM) and G810C/R. |
| PC-23899 |
AH078
CK1δ /CK1ε PROTAC
|
AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform. |
| PC-23854 |
HDAC6 PROTAC A6
HDAC6 PROTAC
|
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells. |
| PC-23853 |
FF2049
HDAC1-3 PROTAC
|
FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells. |
| PC-23842 |
SJ995973
BET PROTAC
|
SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM. |
