| Cat. No. |
Product Name |
Information |
| PC-25285 |
NVS-VHL720
CDO1 degrader
|
NVS-VHL720 is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 71 nM, binds with VHL (binary) with SPR KD of 72 nM, induces CDO1 degradation (absDC50 of 8 nM/98% degradation) in HEK293T cells. |
| PC-25284 |
NVS-VHL097
CDO1 degrader
|
NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells. |
| PC-25266 |
MCB-36
KRAS PROTAC
|
MCB-36 a potent, selective pan-KRAS PROTAC degrader, effectively reduces both KRAS and p-ERK protein levels, binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities (Kd =1 pM). |
| PC-25247 |
S3D5
STAT3 PROTAC
|
S3D5 is a potent and selective, BP-1-102-based PROTAC degrader for STAT3 with DC50 of 110 nM in HepG2 cells. |
| PC-25213 |
HPK1 PROTAC 10m
HPK1 PROTAC
|
HPK1 PROTAC 10m is a potent, selective and orally active HPK1 (MAP4K1) PROTAC degrader with DC50 of 5.0 nM, Dmax ≥ 99% in Jurkat cells. |
| PC-25199 |
TQ-3959
BTK PROTAC
|
TQ-3959 is a potent, selective and orally bioavailable BTK PROTAC degrader with DC50 of 0.4 nM in OCI-Ly10 cell line using an HTRF assay, Dmax=97.7%. |
| PC-25183 |
MGD-22
IKZF1/2/3 degrader
|
MGD-22 is a potent, selective and triple Ikaros proteins IKZF1/2/3 degrader with DC50 of 8.33/9.91/5.74 nM respectively in NCI-H929 cells, all Emax>90%. |
| PC-25160 |
FAK PROTAC FC-11
FAK degrader
|
FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells. |
| PC-25158 |
FAK PROTAC D4
FAK degrader
|
FAK PROTAC D4 is a potent and highly selective FAK PROTAC degrader with DC50 of 1.08 nM in PA-1 cells. |
| PC-25153 |
AURKB PROTAC MS44
Aurora kinase B PROTAC
|
AURKB PROTAC MS44 is a potent, selective, first-in-class Aurora B kinase (AURKB) PROTAC degrader with DC50 of 103 nM in HPAF-11 cells, Dmax of 89%. |
| PC-24992 |
JMV7048
PXR PROTAC
|
JMV7048 is a potent, selective and effective PROTAC degrader of pregnane X receptor (PXR) with DC50 of 379 nM. |
| PC-24991 |
MI1013
PXR PROTAC
|
MI1013 is a potent, selective CRBN-base PROTAC degrader of pregnane X receptor (PXR) designed by connecting SPA70 and pomalidomide with PEG linker, has DC50 of 89 nM and Dmax of 82% in HepaRG cells. |
