| Cat. No. |
Product Name |
Information |
| PC-23329 |
BRD9 PROTAC C6
BRD9 PROTAC
|
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7. |
| PC-23323 |
BET PROTAC SIM1
BRD2 PROTAC
|
BET PROTAC SIM1 is a highly potent, von Hippel-Lindau (VHL)-based BET trivalent PROTAC degrader with preference for BRD2 with DC50 of 1.1 nM, 3.3 nM and 0.7 nM for RD2, BRD3, BRD4 in HEK293 cells, potently inhibits cell viability of MV4;11 AML cell line with IC50 of 1.1 nM (48 h). |
| PC-23305 |
pan-KRAS degrader 4
pan-KRAS PROTAC
|
pan-KRAS degrader 4 is a potent, selective, reversible heterobifunctional pan-KRAS PROTAC degrader with Dmax50 of 17 nM in GP5d cells, efficiently degrades 13 of the 17 most prevalent KRAS mutant alleles and KRASWT with single-digit nanomolar potency. |
| PC-23302 |
SIAIS562055
SOS1 PROTAC
|
SIAIS562055 is a potent, selective SOS1 PROTAC degrader (KD=95.9 nM) which is designed by connecting a CRBN ligand to an analogue of the SOS1 inhibitor BI-3406, selectively degrades SOS1 with DC50 values of 62.5 nM and 8.4 nM in K562 and KU812 cells. |
| PC-23276 |
DD205-291
HPK1 PROTAC
|
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM. |
| PC-23265 |
LDD 39
RET degrader
|
LDD 39 is a pyrazolopyridine-based heterobifunctional RET ligand-directed degrader with IC50 of 2.0/1.1/7.5 nM for WT RET/V804M/G810R respectively, and DC50 of 0.97/3.2/6.4 nM in TPC-1 cells against both RET WT and the two mutants. |
| PC-23239 |
SZU-B6
SIRT6 PROTAC
|
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively. |
| PC-23233 |
DYR684
DYRK1 PROTAC
|
DYR684 is a potent, and selective PROTAC degrader of DYRK1 with KD of 6.3/16 nM for DYRK1A/DYRK1B, DC50 value of 12.3 nM for DYRK1A in HEK293 cells. |
| PC-23208 |
CFT-1297
BRD4 PROTAC
|
CFT-1297 is a potent, selective BRD4 PROTAC degrader with DC50 of 5 nM and Dmax of 97% in HEK293T cells, targets the BD1 domain of BRD4. |
| PC-23176 |
AK-1690
STAT6 PROTAC
|
AK-1690 is the first, potent and selective PROTAC STAT6 degrader with DC50 of 1 nM in MV4;11 cells, Dmax>95%. |
| PC-23155 |
ZLC491
CDK12/13 PROTAC
|
ZLC491 is a potent, selective, and orally bioavailable CDK12/13 PROTAC degrader with DC50 values of 32 and 28 nM, respectively, in TNBC MDA-MB-231 cells. |
| PC-23148 |
YJ9069
CDK12/13 PROTAC
|
YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers. |
