| Cat. No. |
Product Name |
Information |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
| PC-25851 |
D16-M1P2
PKMYT1 PROTAC
|
D16-M1P2 is a potent, highly specific, bifunctional PKMYT1-targeting PROTAC degrader with DC50 of 0.7 nM and Dmax of 90% in HCC1569 cells. |
| PC-25840 |
GSK3 degrader KH1
GSK3 PROTAC
|
GSK3 degrader KH1 is a potent, CNS in vivo active GSK3 PROTAC degrader with DC50 of 1.4 nM in HEK293 cells, induces almost complete GSK3α and GSK3β degradation at 10 nM in HEK293 cells (2 h). |
| PC-25824 |
DDO3602
PARP1 HSPTAC
|
DDO3602 is a potent, effective small molecule HSP90-mediated proteolysis-targeting chimera (HSPTAC) degrader of PARP1 with DC50 of 490.3 nM in MCF-7 cells, induces PARP1 degradation through a multi-E3 ubiquitin ligase-mediated degradation pathway. |
| PC-25742 |
WZS0347
MITF PROTAC
|
WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells. |
| PC-25679 |
G-6599
SMARCA2/A4 degrader
|
G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22. |
| PC-25674 |
AMPTX1
BRD9 degrader
|
AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h). |
| PC-25670 |
Golcadomide
IKZF1/3 degrader
|
Golcadomide (CC-99282) is a potent, oral cereblon-modulating CELMoD agent that acts as cereblon-based molecular glue degrader of both IKZF1 and IKZF3. |
| PC-25655 |
EPIC-0726
PTRF PROTAC
|
EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%. |
| PC-25623 |
MA203
CHK1 PROTAC
|
MA203 is a potent, selective Checkpoint kinase-1 (CHK1) PROTAC degarder with DC50 of 5 uM in MIA PaCa-2 (24 h). |
| PC-25610 |
ZJK-807
KRAS G12D PROTAC
|
ZJK-807 is a selective, cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC) degrader of KRASG12D with DC50 of 79.5 nM in AsPC-1 cells (Dmax=92%), with minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D) KRAS proteins. |
| PC-25493 |
FTO degrader FP54
FTO PROTAC
|
FTO degrader FP54 is a selective PROTAC degrader of fat mass and obesity-associated protein (FTO) with DCof 0.68 μM in NB4 cells and 0.71 μM in MOLM-13 cells, Dmax>95%. |
