| Cat. No. |
Product Name |
Information |
| PC-21323 |
NX-5948
BTK PROTAC
|
NX‑5948 (NX5948) is a potent, selective and brain-penetrant degrader of BTK with DC50 of <1 nM in lymphoma cell lines and peripheral blood mononuclear cells (PBMCs). |
| PC-21276 |
JWZ-1-80
PI5P4Kγ PROTAC
|
JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells. |
| PC-21161 |
ARD-2051
AR PROTAC
|
ARD-2051 (ARD-2051) is a potent and orally efficacious androgen receptor (AR) proteolysis-targeting chimera (PROTAC) degrader with DC50 of 0.6 nM in AR+ VCaP and LNCaP cell lines. |
| PC-21160 |
ARD-1676
AR PROTAC
|
ARD-1676 (ARD1676) is a highly potent and orally efficacious PROTAC degrader of the androgen receptor (AR) with DC50 values of 0.1 and 1.1 nM in AR+ VCaP and LNCaP cell lines, respectively. |
| PC-21143 |
YX968
HDAC3/8 PROTAC
|
YX968 is a potent, selecive HDAC3/8 dual PROTAC degrader with DC50 of 1.7 and 6.1 nM in degrading HDAC3 and HDAC8 respectively (MDA-MD-231 cell, 8 h). |
| PC-21127 |
TD-802
AR PROTAC
|
TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells. |
| PC-21126 |
ARD-2128
AR PROTAC
|
ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line. |
| PC-21125 |
ARD-2585
AR PROTAC
|
ARD-2585 is a potent and orally bioavailable PROTAC androgen receptor (AR) degrader with DC50 of 0.04 nM, Dmax=99% in VCaP cell line. |
| PC-21124 |
MTX-23
AR PROTAC
|
MTX-23 is a proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) splice variant-7 (AR-V7) and AR-full length (AR-FL) with DC50 of 0.37 and 2 uM, respectively. |
| PC-21123 |
BWA-522
AR PROTAC
|
BWA-522 is a potent, orally bioavailable PROTAC degrader of the androgen receptor N-terminal domain (AR-NTD), induces AR-FL or AR-V7 protein degradationwith DC50 of 0.73 μM (AR-FL) and 0.67 μM (AR-V7) in VCaP cells. |
| PC-21116 |
PDCD2 degrader 10e
PDCD2 PROTAC
|
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity. |
| PC-21068 |
JH-XII-03-02
LRRK2 PROTAC
|
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S. |
