| Cat. No. |
Product Name |
Information |
| PC-27387 |
dWBP4-1
WBP4 degrader
|
dWBP4-1 is a potent, highly selective, CRBN-dependent, phenotypically silent molecular glue degrader of spliceosome-associated scaffold protein WBP4 with DC50 of 3.4 nM in in MOLT-4 cells (Dmax=88%, 6h). |
| PC-27354 |
c-MET PROTAC D15
c-MET degrader
|
c-MET PROTAC D15 is a potent, selective and orally active c-MET PROTAC degrader with DC50 of 0.44 nM and 0.35 nM in EBC-1 and Hs746T cells respectively (Dmax >99%). |
| PC-27299 |
SK-3-91
multi-kinase PROTAC
|
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes. |
| PC-27259 |
SD-2301
STAT3 PROTAC
|
SD-2301 is a highly potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 4 nM, Dmax of >95% in HiBiT assays using HeLa cell line. |
| PC-27236 |
NUCC-0227579
CD73 PROTAC
|
NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways. |
| PC-27235 |
XZ8078
PARP1/IKZF3 degrader
|
XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM. |
| PC-27227 |
APH02174
IRAK4 PROTAC
|
APH02174 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 4.01 nM, Dmax=94%. |
| PC-27226 |
APH003
IRAK4 PROTAC
|
APH003 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 1.28 nM, DC90=6.39 nM. |
| PC-27220 |
DW-229
KDM PROTAC
|
DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. |
| PC-27200 |
JHK-02-108-2
CDK6 PROTAC
|
JHK-02-108-2 is a potent, selective, type II, heterobifunctional CDK6 PROTAC degrader with DC50 of 11 nM in MOLT-4 cells, does not induce CDK5 degradation. |
| PC-27167 |
NSD2 degrader T9
NSD2 degrader
|
NSD2 degrader T9 is a potent, selective, FBXO22-recruiting NSD2 degrader with DC50 of 0.37 uM in in HEK293T-NSD2-HiBiT cells (4 h). |
| PC-27164 |
RAD51 PROTAC G73
RAD51 PROTAC
|
RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells. |
