| Cat. No. |
Product Name |
Information |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-22174 |
MS181
PRC1 degrader
|
MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12. |
| PC-22157 |
MS8709
G9a/GLP degrader
|
MS8709 is a potent, selective first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader with DC50 of 274/260 nM in 22Rv1 cells, respectively. |
| PC-22155 |
MPD2
SARS-CoV-2 Mpro degrader
|
MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism. |
| PC-22126 |
LD4172
RIPK1 degrader
|
LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines. |
| PC-22117 |
BMS-986365
AR degrader
|
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR. |
| PC-22099 |
MS170
AKT PROTAC degrader
|
MS170 (AKT PROTAC degrader) is a potent, selective, cereblon (CRBN)-recruiting AKT PROTAC degrader with DC50 of 32 nM (cellular T-AKT in BT474 cells). |
| PC-22098 |
MS98
AKT PROTAC degrader
|
MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM. |
| PC-22097 |
WH244
BCL-xL/BCL-2 PROTAC
|
WH244 is a potent second-generation dual PROTAC degrader of BCL-2 and BCL-xL with DC50 of 0.6 nM (BCL-xL) and 7.4 nM (BCL-2) in Jurkat cells. |
