| Cat. No. |
Product Name |
Information |
| PC-49439 |
CRBN(FLT3)-8
FLT3-ITD degarder
|
CRBN(FLT3)-8 a highly potent FLT3 degrader by introducing gilteritinib into targeted protein degradation technology, potently degrades FLT3-ITD via UPS and inhibits the proliferation of FLT3-ITD mutant AML cells more effectively than gilteritinib. |
| PC-49352 |
AZ6421
ER PROTAC
|
AZ'6421 is a Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor, shows ER binding and ER degradation with IC50 and DC50 values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines. |
| PC-49328 |
HPP-9
BET PROTAC
|
HPP-9 is a potent BET bromodomain degrader that acts through a PROTAC mechanism, HPP-9 is a long-acting Hedgehog pathway inhibitor. |
| PC-49310 |
SJPYT-195
GSPT1 PROTAC
|
SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein. |
| PC-49282 |
XL01126
LRRK degrader
|
XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h. |
| PC-49151 |
QA-68-ZU81
BRD9 degrader
|
QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC). |
| PC-47084 |
JCS-1
DcpS PROTAC
|
JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines. |
| PC-38903 |
U7D-1
USP7 PROTAC
|
U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC). U7D-1 showed selective and effective USP7 degradation, and maintained potent cell growth inhibition in p53 mutant cancer cells. |
| PC-38738 |
Degradomer D-1
IRAK3 degarder
|
Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM). |
| PC-38718 |
CRBN(BRAF)-24
BRAF V600E PROTAC
|
CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells. |
| PC-38566 |
STING PROTAC SP23
STING PROTAC
|
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM. |
| PC-38462 |
dBRD9 dihydrochloride
BRD9 PROTAC
|
dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
