| Cat. No. |
Product Name |
Information |
| PC-23276 |
DD205-291
HPK1 PROTAC
|
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM. |
| PC-23265 |
LDD 39
RET degrader
|
LDD 39 is a pyrazolopyridine-based heterobifunctional RET ligand-directed degrader with IC50 of 2.0/1.1/7.5 nM for WT RET/V804M/G810R respectively, and DC50 of 0.97/3.2/6.4 nM in TPC-1 cells against both RET WT and the two mutants. |
| PC-23239 |
SZU-B6
SIRT6 PROTAC
|
SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively. |
| PC-23233 |
DYR684
DYRK1 PROTAC
|
DYR684 is a potent, and selective PROTAC degrader of DYRK1 with KD of 6.3/16 nM for DYRK1A/DYRK1B, DC50 value of 12.3 nM for DYRK1A in HEK293 cells. |
| PC-23208 |
CFT-1297
BRD4 PROTAC
|
CFT-1297 is a potent, selective BRD4 PROTAC degrader with DC50 of 5 nM and Dmax of 97% in HEK293T cells, targets the BD1 domain of BRD4. |
| PC-23148 |
YJ9069
CDK12/13 PROTAC
|
YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers. |
| PC-23129 |
SIAIS361034
Bcl-xL PROTAC
|
SIAIS361034 is a potent, selective PROTAC degrader of Bcl-xL, selectively degrades Bcl-xL and significantly inhibits the Hh pathway activity SIAIS361034 with IC50 of 120 nM. |
| PC-23104 |
METTL3 PROTAC KH12
METTL3 PROTAC
|
KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells. |
| PC-23062 |
MG-277
GSPT1 degrader
|
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM. |
| PC-23037 |
PROTAC AGB1
BromoTagged proteins PROTAC
|
PROTAC AGB1 is a potent, fast, and selective degrader of BromoTagged proteins with DC50 of <15 nM. |
| PC-22990 |
BRD4 PROTAC 6b
BRD4 PROTAC
|
BRD4 PROTAC 6b is a potent, specific PROTAC degrader of BRD4 protein, suppresses BLBC cell growth by targeting BRD4, but not BRD2 and BRD3, for cereblon (CRBN)-mediated ubiquitination and proteasomal degradation. |
| PC-22970 |
YAP PROTAC YZ-6
YAP PROTAC
|
YAP PROTAC YZ-6 is a selective Yes-associated protein (YAP) PROTAC degrader with DC50 of 8.2 uM in NCI-H226 cells, Dmax value of 97%. |
