| Cat. No. |
Product Name |
Information |
| PC-22538 |
SIAIS039
ROS1 PROTAC
|
SIAIS039 is the first ROS1-specific PROTAC degrader with DC50 of 154.46 nM in HCC78 cells, shows cytotoxic effects in cells carrying ROS1 fusion mutations. |
| PC-22505 |
ZXH-8-004
DENV E protein degrader
|
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase. |
| PC-22493 |
FAK degrader F2
FAK degrader
|
FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells. |
| PC-22486 |
XYD129
CBP/p300 degrader
|
XYD129 is a highly potent and selective CBP/p300 degrader with IC50 of 21/30 nM, effectively degrades CBP/p300 proteins and exhibits potent inhibition of growth in acute leukemia cell lines (MOLM-16, IC50=7.4 nM). |
| PC-22441 |
ARM165
PIK3CG/p110γ degrader
|
ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML. |
| PC-22411 |
HL435
BRD4 degrader
|
HL435 is a potent, alkenyl oxindole-based heterobifunctional BRD4 degrader PROTAC with DC50 values of 11.9 and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. |
| PC-22393 |
WEE1/CK1α degrader 2
WEE1/CK1α degrader
|
WEE1/CK1α degrader 2 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.6/1.5 nM, respectively, Emax >98%. |
| PC-22392 |
WEE1/CK1α degrader 1
WEE1/CK1α degrader
|
WEE1/CK1α degrader 1 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.1/3.1 nM, respectively. |
| PC-22391 |
WEE1 degrader 2
WEE1 degrader
|
WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α. |
| PC-22390 |
WEE1 degrader 1
WEE1 degrader
|
WEE1 degrader 1 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 91 nM, does not degrade CK1α. |
| PC-22339 |
LLC355
DDR1 degrader
|
LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion. |
| PC-22314 |
LC-MI-3
IRAK4 degrader
|
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%. |
