| Cat. No. |
Product Name |
Information |
| PC-28478 |
IAP-08
SMYD3 PROTAC
|
IAP-08 is a potent, selective SMYD3 proteolysis targeting chimera (PROTAC) degrader with DC50 of 177 nM and Dmax of 90% in HiBiT-tagged SMYD3 expressing HN13 cells, effectively induces the formation of ternary complexes with SMYD3 and the XIAP E3 ligase. |
| PC-28444 |
AMC-3-221
CDK9 PROTAC
|
AMC-3-221 is a potent, CDK9-selective PROTAC degrader with DC50 of <10 nM and antileukemic inhibitory potency (IC50<50 nM), shows high selectivity for CDK9 over other family members. |
| PC-28199 |
JH-XIII-05-01
IRAK1/IRAK4 degrader
|
JH-XIII-05-01 is a potent, dual IRAK1/IRAK4 degrader with enzymetic IC50 of 43 nM and 16 nM, DC50 of 65 nM and 3.6 uM respectively. |
| PC-27930 |
NUP214 degrader 0449-b
NUP214 degrader
|
NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells. |
| PC-27878 |
DnAurA-A10
AURKA PROTAC
|
DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells. |
| PC-27854 |
dBAZ2
BAZ2A/B PROTAC
|
dBAZ2 is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2A/B, selectively degrades BAZ2A and BAZ2B with DC50 of 180 nM and 250 nM, and Dmax ≥ 97% in PC3 cells. |
| PC-27853 |
dBAZ2B
BAZ2B PROTAC
|
dBAZ2B is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2B, selectively degrades BAZ2B with DC50 of 19 nM and Dmax ≥ 97% in PC3 cells, does not affect BAZ2A. |
| PC-27685 |
DB-0646
Multi-target PROTAC
|
DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1. |
| PC-27578 |
PinA1 hydrochloride
CK1⍺ degrader
|
PinA1 hydrochloride is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27544 |
SMARCA2 4 MGD Compound 1
SMARCA2/4 degrader
|
SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173. |
| PC-27523 |
MD-4251
MDM2 degrader
|
MD-4251 is a potent, selective and orally efficacious MDM2 PROTAC degrader with DC50 of 0.2 nM in RS4;11 cells (Dmax=96% at 2 h), leading to robust p53 activation. |
| PC-27389 |
NE26394
CDK4 degrader
|
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins. |
