| Cat. No. |
Product Name |
Information |
| PC-60125 |
CC-885
GSPT1 PROTAC
|
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
| PC-60121 |
SNIPER(ABL)-062
BCR-ABL degrader
|
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation. |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-24506 |
LZK PROTAC 17
LZK degrader
|
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM. |
| PC-24493 |
YD54
SMARCA2 PROTAC
|
YD54 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 1.2 nM (H322 cell ine), Dmax=99.3%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
| PC-24492 |
YDR1
SMARCA2 PROTAC
|
YDR1 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 6.3 nM (H322 cell ine), Dmax=99.4%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
