| Cat. No. |
Product Name |
Information |
| PC-38054 |
DT2216
BCL-XL PROTAC
|
DT2216 (DT-2216) is a specific BCL-XL PROTAC by linking ABT263 to a VHL ligand (VHL-L), induces BCL-XL degradation in MOLT-4 T-ALL cells with DC50 of 63 nM. |
| PC-38047 |
Bavdegalutamide
AR degrader
|
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR with DC50 of <1 nM. |
| PC-38019 |
dCBP-1
p300/CBP PROTAC
|
dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC. |
| PC-36151 |
NRX-252114
|
NRX-252114 (NRX 252114, NRX252114) is a potent, small molecule β-TrCP-based degrader of β-catenin, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM). |
| PC-35936 |
BSJ-03-123
CDK6 PROTAC
|
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions. |
| PC-35882 |
VZ185
BRD9 PROTAC
|
VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively. |
| PC-35859 |
FKBP12 PROTAC dTAG-13
FKBP12 degrader
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells. |
| PC-35858 |
FKBP12 PROTAC dTAG-7
FKBP12 degrader
|
FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells. |
| PC-35668 |
GSK983
PCAF/GCN5 PROTAC
|
GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively. |
| PC-35667 |
GSK699
PCAF/GCN5 PROTAC
|
GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells. |
| PC-35215 |
dBET57
|
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
| PC-35152 |
TL13-112
|
TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide. |
