| Cat. No. |
Product Name |
Information |
| PC-23133 |
SMARCA2 PROTAC YD23
SMARCA2 PROTAC
|
SMARCA2 PROTAC YD23 is a potent and selective proteolysis targeting chimera (PROTAC) targeting SMARCA2 with DC50 of 64 nM in H1792 cells and Dmax of 88%. |
| PC-23129 |
SIAIS361034
Bcl-xL PROTAC
|
SIAIS361034 is a potent, selective PROTAC degrader of Bcl-xL, selectively degrades Bcl-xL and significantly inhibits the Hh pathway activity SIAIS361034 with IC50 of 120 nM. |
| PC-23104 |
METTL3 PROTAC KH12
METTL3 PROTAC
|
KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells. |
| PC-23063 |
BTX-1188
GSPT1 and IKZF1/3 PROTAC
|
Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells. |
| PC-23062 |
MG-277
GSPT1 degrader
|
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM. |
| PC-23037 |
PROTAC AGB1
BromoTagged proteins PROTAC
|
PROTAC AGB1 is a potent, fast, and selective degrader of BromoTagged proteins with DC50 of <15 nM. |
| PC-22990 |
BRD4 PROTAC 6b
BRD4 PROTAC
|
BRD4 PROTAC 6b is a potent, specific PROTAC degrader of BRD4 protein, suppresses BLBC cell growth by targeting BRD4, but not BRD2 and BRD3, for cereblon (CRBN)-mediated ubiquitination and proteasomal degradation. |
| PC-22970 |
YAP PROTAC YZ-6
YAP PROTAC
|
YAP PROTAC YZ-6 is a selective Yes-associated protein (YAP) PROTAC degrader with DC50 of 8.2 uM in NCI-H226 cells, Dmax value of 97%. |
| PC-22963 |
ENL degrader MS41
ENL PROTAC
|
MS41 is a potent and selective, VHL-recruiting ENL PROTAC degrader, induces robust ENL degradation in a variety of human leukemia cell lines with DC50 of 3.50, 2.84, 3.03, and 26.58 nM in MV4;11, SEMK2, Jurkat, and KASUMI1, respectively, Dmax>93%. |
| PC-22940 |
CBPD-268
CBP/p300 PROTAC
|
CBPD-268 is a potent, effective, and orally efficacious PROTAC degrader of CBP/p300 proteins DC50 of 0.5 nM against CBP and DC50 of 0.8 nM against p300 and Dmax of 100% against both proteins in the HiBit assays. |
| PC-22939 |
CW-3308
BRD9 PROTAC
|
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line. |
| PC-22938 |
YZ167
HDAC6 PROTAC
|
YZ1678 is a potent, selective HDAC6 PROTAC degrader with DC50 of 1.94 nM in MM.1S cells. |
