| Cat. No. |
Product Name |
Information |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-24975 |
SD-91
STAT3 PROTAC
|
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line. |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24668 |
BMS-986458
BCL6 degrader
|
BMS-986458 is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader with CRBN binding IC50 of 41 nM, and BCL-6 degradation of 0.2 nM in OCI-LY-1 cells (2 h). |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader (DC50<40 nM in THP-1 cells), effectively degrades LSD1 in a concentration-, time-, and proteasome-dependent manner. |
| PC-24555 |
PLX-4545
IKZF2 degrader
|
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity. |
| PC-24554 |
PVTX-405
IKZF2 degrader
|
PVTX-405 is a potent, highly selective, rapid and orally efficacious CRBN-dependent glue degrader of IKZF2 with DC50 of 0.7 nM in IKZF2 HiBiT degradation assay in HEK293 cells, Dmax = 91%. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-24090 |
cGAS PROTAC TH35
cGAS degrader
|
cGAS PROTAC TH35 is an effective, selective CRBN-recruiting cGAS-targeting PROTAC degrader with DC50 of 0.9 uM and 4.6 uM in THP-1 and RAW 264.7 cells respectively, Dmax >90% at 20 uM. |
