| Cat. No. |
Product Name |
Information |
| PC-24732 |
Aster-A PROTAC NGF3
Aster-A degrader
|
Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells. |
| PC-24675 |
Linker-free PROTAC Pro-DA
BCR-ABL degrader
|
Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM. |
| PC-24674 |
Linker-free PROTAC Pro-BA
EML4-ALK degrader
|
Linker-free PROTAC Pro-BA is a linker-free PROTAC degarder of EML4-ALK protein with DC50 of 74 nM and achieves an 82% reduction at 500 nM in H3122 cells, shows cell growth IC50 of 34 nM. |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4). |
| PC-24663 |
GDC-2992
AR PROTAC
|
GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells. |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24575 |
RP03707
KRAS G12D PROTAC
|
RP03707 is a CRBN-involving, highly potent, and selective KRAS G12D PROTAC degrader with DC50 of 0.7 nM in PK-59 cells (Dmax=96%). |
| PC-24558 |
MNK1 PROTAC P11-2
MNK1 PROTAC
|
MNK1 PROTAC P11-2 is a first-in-class, selective MNK1-targeting PROTAC degrader with DC50 of 11.92 nM (MV4-11 cells), Dmax>96%, shows remarkable selectivity for MNK1 over MNK2. |
| PC-24557 |
ERD-1233
ERα degrader
|
ERD-1233 is a potent and orally efficacious PROTAC degrader of estrogen receptor α (ERα) with DC50 of 0.9 nM in MCF-7 cell line, Dmax=100%. |
| PC-24551 |
BD-9136
BRD4 degrader
|
BD-9136 is a potent, highly selective PROTAC degrader of BRD4 with DC50 of 1.2 nM (MV-4-11 cell, 4 h), Dmax=99%, displays >1000-fold selective over BRD2 and BRD3 proteins. |
| PC-24506 |
LZK PROTAC 17
LZK degrader
|
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM. |
| PC-24493 |
YD54
SMARCA2 PROTAC
|
YD54 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 1.2 nM (H322 cell ine), Dmax=99.3%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
