| Cat. No. |
Product Name |
Information |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-27930 |
NUP214 degrader 0449-b
NUP214 degrader
|
NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells. |
| PC-27878 |
DnAurA-A10
AURKA PROTAC
|
DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells. |
| PC-27854 |
dBAZ2
BAZ2A/B PROTAC
|
dBAZ2 is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2A/B, selectively degrades BAZ2A and BAZ2B with DC50 of 180 nM and 250 nM, and Dmax ≥ 97% in PC3 cells. |
| PC-27853 |
dBAZ2B
BAZ2B PROTAC
|
dBAZ2B is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2B, selectively degrades BAZ2B with DC50 of 19 nM and Dmax ≥ 97% in PC3 cells, does not affect BAZ2A. |
| PC-27685 |
DB-0646
Multi-target PROTAC
|
DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1. |
| PC-27578 |
PinA1 hydrochloride
CK1⍺ degrader
|
PinA1 hydrochloride is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27544 |
SMARCA2 4 MGD Compound 1
SMARCA2/4 degrader
|
SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173. |
| PC-27523 |
MD-4251
MDM2 degrader
|
MD-4251 is a potent, selective and orally efficacious MDM2 PROTAC degrader with DC50 of 0.2 nM in RS4;11 cells (Dmax=96% at 2 h), leading to robust p53 activation. |
| PC-27389 |
NE26394
CDK4 degrader
|
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins. |
