| Cat. No. |
Product Name |
Information |
| PC-26814 |
HMGCS1 inhibitor CNP7
HMGCS1 inhibitor
|
CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation. |
| PC-26793 |
MDC134
Insulinotropic molecule
|
MDC134 is a glucose-dependent insulinotropic small molecule that enhances β-cell insulin secretion in pancreatic β-cells through Ca2+ influx and cAMP-associated amplification. |
| PC-26779 |
(Z)-Ligustilide
CAS 81944-09-4
|
(Z)-Ligustilide is an orally active natural compound from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD). |
| PC-26778 |
Ligustilide
MEOX1 inhibitor
|
Ligustilide is a potential inhibitor of mesenchyme homeobox 1 (MEOX1), exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects, exerts significant antifibrotic effects through inhibition of MEOX1 and the downstream of the Hippo signalling pathway. |
| PC-26769 |
MEDS700
DHODH inhibitor
|
MEDS700 is a potent, selective, blood-brain barrier permeable hDHODH inhibitor with IC50 of 1.5 nM. |
| PC-26744 |
TTBK1-IN-2
TTBK1 inhibitor
|
TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo. |
| PC-26724 |
MS351
CBX7 inhibitor
|
MS351 (MS-351) is a specific small molecule antagonist of chromobox 7 (CBX7) chromodomain (CBX7ChD) with Kd of approximately 500 uM by NMR titration, disrupts H3K27me3-mediated CBX7 binding to target genes in chromatin. |
| PC-26717 |
HF-125
TRIB2 inhibitor
|
HF-125 is a potent, selective small molecule inhibitor of Tribbles 2 (TRIB2), directly binds to destabilize and degrade TRIB2 proteins involving proteasomes and is effective both in vitro and in vivo. |
| PC-26684 |
LMT328
Sulfiredoxin inhibitor
|
LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM. |
| PC-26649 |
mtCI modulator C273
Mitochondrial complex I inhibitor/modulator
|
mtCI modulator C273 is a selective, brain-penetrant, orally bioavailable small molecule modulator/ weak inhibitor of mitochondrial complex I (mtCI) with IC50 of 201.5 uM, protects against Aβ toxicity through mtCI modulation. |
| PC-26615 |
ERG245
BCAT1 inhibitor
|
ERG245 is a potent, selective BCAT1 inhibitor with IC50 of 0.5 nM for recombinant human BCAT1 (rhBCAT1), >2000-fold selectivity for BCAT1 over BCAT2. |
| PC-26613 |
ERG240
BCAT1 inhibitor
|
ERG240 (ERG-240) is a potent, selective, orally active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor, inhibits recombinant BCAT1 with an IC50 of 0.1-1 nM, with no inhibition on BCAT2. |
