| Cat. No. |
Product Name |
Information |
| PC-25712 |
RWT9996
GPR17 antagonist
|
RWT9996 is a potent, selective GPR17 antagonist, inhibits both G protein activation and β-arrestin-2 recruitment. |
| PC-25706 |
hCES2A inhibitor C3
hCES2A inhibitor
|
hCES2A inhibitor C3 is a highly potent, orally active and serine-targeting covalent inhibitor of hCES2A (human carboxylesterase 2A) with IC50 of 0.56 nM, Ki of 1.58 nM. |
| PC-25702 |
ARN14686
NAAA probe
|
ARN14686 is a click chemistry activity-based probe (CC-ABP) that selectively recognizes the enzyme N-acylethanolamine acid amidase (NAAA). |
| PC-25694 |
Auxurea A
GH3 inhibitor
|
Auxurea A is a selective competitive small molecule inhibitor of IAA-amino acid conjugating enzymes GH3, specifically inhibited GH3-mediated IAA inactivation both in vivo and in vitro, induces high-auxin phenotypes in Arabidopsis. |
| PC-25661 |
TDRL-505
RPA inhibitor
|
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA. |
| PC-25635 |
TTZ-2
zDHHC2 inhibitor
|
TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 1.3 uM. |
| PC-25595 |
AEPU
sEH inhibitor
|
AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model. |
| PC-25592 |
DCLK1 inhibitor 12n
DCLK1 inhibitor
|
DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM. |
| PC-25581 |
FOXA1/2 inhibitor compound T
FOXA1/2 inhibitor
|
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupt the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM. |
| PC-25568 |
ELOVL6 inhibitor 1w
ELOVL6 inhibitor
|
ELOVL6 inhibitor 1w (ELOVL6-IN-4) is a potent, selective, and orally available ELOVL6 (long chain fatty acid elongase 6) inhibitor with IC50 of 79 and 94 nM for human and mouse ELOVL6 respectively. |
| PC-25561 |
BI 1595043
Vanin inhibitor
|
BI 1595043 is a potent, selective and orally bioavailable Vanin (vanin‐1 and vanin‐2) inhibitor, demonstrates promising effects on epithelial cell protection and reduction of inflammatory mediators in preclinical studies. |
| PC-25558 |
KCB3602
Lin28-let-7 inhibitor
|
KCB3602 is a specific small-molecule inhibitor of the Lin28–let-7 interaction with IC50 of 4.8 uM in EMSA assays, shows direct binding to Lin28a with SPR KD of 5.9 uM. |
