| Cat. No. |
Product Name |
Information |
| PC-61796 |
Trofinetide
|
Trofinetide (NNZ 2566) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration. |
| PC-61784 |
NSC 15765
DNA2 nuclease inhibitor
|
NSC 15765 (Compound C5, DNA2 inhibitor C5) is an effective, selective and competitive inhibitor of DNA2 nuclease with IC50 of 20 uM. |
| PC-61782 |
J147
Neuroprotective agent
|
J 147 is a potent, orally active, memory enhancing and neurotrophic agent that protects against neurotoxicity in cortical neurons in vitro with EC50 of 25-200 nM. |
| PC-61781 |
CAD-031
Neuroprotective agent
|
CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs). |
| PC-61734 |
R-283
hTG2 inhibitor
|
R-283 is a potent and selective human tissue transglutaminase (hTG2) inhibitor with IC50 of 4 uM.. |
| PC-61677 |
ATN-224
SOD1 inhibitor
|
ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects. |
| PC-61674 |
SBI-993
MondoA inhibitor
|
SBI-993 is an analog of SBI-477 that shows improved potency and suitable pharmacokinetic properties for in vivo bioavailability. |
| PC-61673 |
SBI-477
MondoA inhibitor
|
SBI-477 is a chemical probe that coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes with EC50 of 100 nM and 1 uM, respectively. |
| PC-61554 |
NCGC00185684
|
NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor. |
| PC-61485 |
VJ115
ENOX1 inhibitor
|
VJ115 (VJ-115) is a small molecule inhibitor of NADH oxidase ENOX1 with IC50 of 10 uM, increases intracellular NADH in endothelial cells and inhibits endothelial cell tubule formation. |
| PC-61473 |
BI 1467335
|
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM. |
| PC-61463 |
VPC-18005
|
VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM). |
