| Cat. No. |
Product Name |
Information |
| PC-25795 |
ASX-173
Asparagine synthetase inhibitor
|
ASX-173 is a selective, cell-penetrable small molecule inhibitor of human asparagine synthetase (ASNS), inhibits L-asparagine production with IC50 of 0.5 uM,, induces the integrated stress response (ISR), and reduces cell growth in HEK-293A cells. |
| PC-25784 |
ML345
IDE inhibitor, NLRP3 inhibitor
|
ML345 is a potent, selective Insulin-degrading enzyme (IDE, Insulysin) with IC50 of 188 nM, targets a specific cysteine residue (Cys819) in IDE, also is a highly potent and selective NLRP3 inhibitor, directly targets tyrosine 381 (Y381) and disrupts its essential interaction with NIMA-related kinase 7 (NEK7). |
| PC-25765 |
TRF1-TIN2 interaction inhibitor 1
TRF1 inhibitor
|
TRF1-TIN2 interaction inhibitor 1 (Compound 40) is a first-in-class inhibitor of the TRF1:TIN2 interaction with IC50 of 67 uM, binds to TRFH domain of TRF1 (TRF1 TRFH) with KD of 29 uM, disrupts shelterin complex assembly. |
| PC-25748 |
PKSI-527
Plasma kallikrein inhibitor, PLK inhibitor
|
PKSI-527 is a highly selective plasma kallikrein inhibitor, suppresses collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system, also is a selective PLK inhibitor. |
| PC-25741 |
SB-633825
TIE2 inhibitor, STK10 inhibitor
|
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively, inhibits cancer cell growth and angiogenesis. |
| PC-25740 |
STK10 inhibitor 23
STK10 inhibitor
|
STK10 inhibitor 23 is a potent, selective inhibitor of STK10 (serine/threonine kinase 10, LOK) with IC50 of 0.85 uM. |
| PC-25732 |
RUVBL1/2 ATPase-IN-1
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/2 ATPase-IN-1 is a small-molecule inhibitor of RUVBL1/2 ATPase with IC50 of 6.0 uM and 7.7 uM against RUVBL1/2 complex and RUVBL1 respectively. |
| PC-25731 |
RUVBL1/RUVBL2 inhibitor Compound B
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/RUVBL2 inhibitor Compound B is a potent, specific and orally bioavailable RUVBL1/2 ATPase (pontin/TIP49 and reptin/TIP48) inhibitor with IC50 of 59 nM. |
| PC-25725 |
PYCR1-IN-1
PYCR1 inhibitor
|
PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM. |
| PC-25712 |
RWT9996
GPR17 antagonist
|
RWT9996 is a potent, selective GPR17 antagonist, inhibits both G protein activation and β-arrestin-2 recruitment. |
| PC-25706 |
hCES2A inhibitor C3
hCES2A inhibitor
|
hCES2A inhibitor C3 is a highly potent, orally active and serine-targeting covalent inhibitor of hCES2A (human carboxylesterase 2A) with IC50 of 0.56 nM, Ki of 1.58 nM. |
| PC-25702 |
ARN14686
NAAA probe
|
ARN14686 is a click chemistry activity-based probe (CC-ABP) that selectively recognizes the enzyme N-acylethanolamine acid amidase (NAAA). |
