| Cat. No. |
Product Name |
Information |
| PC-21724 |
L6H21
MD-2 inhibitor
|
L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex. |
| PC-21705 |
KVS0001
SMG1 inhibitor
|
KVS0001 is a specific and bioavailable small molecule inhibitor of SMG1 kinase, disrupts nonsense mediated decay (NMD). |
| PC-21701 |
SKOG102
OLIG2 inhibitor
|
SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM. |
| PC-21687 |
BCL3ANT
Bcl-3 inhibitor
|
BCL3ANT (NSC-659509) is a small molecule inhibitor of Bcl-3-mediated cyclin D1 expression, reduces cyclin D1 luciferase activity in Bcl-3-overexpressing melanoma cells with IC50 of 40.4 uM. |
| PC-21665 |
VY-3-249
ACSS2 inhibitor
|
VY-3-249 is a a potent Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 1.2 uM in in vitro biochemical TranScreener assays. |
| PC-21664 |
AD-8007
ACSS2 inhibitor
|
AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells. |
| PC-21663 |
AD-5584
ACSS2 inhibitor
|
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells. |
| PC-21646 |
Siastatin B
Glycosidase inhibitor
|
Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases. |
| PC-21645 |
Voclosporin
Calcineurin inhibitor
|
Voclosporin (ISATX247, ISA247) is a small molecule calcineurin inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production. |
| PC-21635 |
Equilin
3βHSD1 inhibitor
|
Equilin (7-Dehydroestrone) is a highly potent 3βHSD1 inhibitor with IC50 of 2.8 nM in VCaP cells, also inhibits the activity of purified 3βHSD1 with SPR KD of 2.23 uM. |
| PC-21630 |
QP5038
QPCTL inhibitor
|
QP5038 is a potent inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 3.8 nM, shows promising in vitro and in vivo anti-tumor efficacies. |
| PC-21628 |
RBS-10
NQO1 inhibitor
|
RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1. |
