| Cat. No. |
Product Name |
Information |
| PC-72855 |
Pixatimod
Heparanase inhibitor
|
Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase. |
| PC-72846 |
Simufilam hydrochloride
Filamin A corrector
|
Simufilam hydrocloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation. |
| PC-72838 |
KM04794
UPR inhibitor
|
KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM. |
| PC-72833 |
ChemR23 inhibitor 14f
ChemR23 inhibitor
|
ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs). |
| PC-72831 |
Nek1 inhibitor 10f
Nek1 inhibitor
|
Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM. |
| PC-72819 |
SID7969543
SF-1/NR5A1 inhibitor
|
SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells. |
| PC-72813 |
SOCS1 inhibitor 20
SOCS1 inhibitor
|
SOCS1 inhibitor 20 is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1) |
| PC-72812 |
TLX agonist 10
TLX (NR2E1) agonist
|
TLX agonist 10 is potent, selective agonist of the orphan nuclear receptor tailless homologue (TLX, NR2E1) with pEC50 of 6.6 |
| PC-72761 |
UbV SP.3
STAMBP inhibitor
|
UbV SP.3 is potent, selective inhibitor of STAMBP isopeptidase activity with KD/IC50 of 60/9.8 nM, with significant preferential binding to STAMBP over STAMBPL1 (250 -fold selectivity). |
| PC-72760 |
UbV SP.1
STAMBP inhibitor
|
UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively. |
| PC-72756 |
TTFB
ZAC antagonist
|
TTFB (ZAC antagonist TTFB) is a selective antagonist (negative allosteric modulator) of Zinc-Activated Channel (ZAC) with IC50 of 3 uM. |
| PC-72746 |
Sari 59-801
|
SaRI 59-801 is an orally effective hypoglycemic compound, decreases blood glucose in several species and to elevate plasma insulin in rats and mice. |
