| Cat. No. |
Product Name |
Information |
| PC-42293 |
EC330
LIF inhibitor
|
EC330 (EC-330, EC 330) is a first-in-class, orally bioavailable LIF (leukemia inhibitory factor, LIFR) inhibitor. |
| PC-45088 |
SP-420
Iron chelating agent
|
Petadeferitrin (SP-420) is a desferrithiocin analogue and iron chelating agent that has iron-clearing efficiency with ICE value of 26.7, SP-420 is more potent than desferrithiocin. |
| PC-45513 |
HQ-415
Metal chelator, TDP-43 modulator
|
HQ-415 is a derivative of 8-hydroxyquinoline that has selectivity for rescuing the distinct toxicities caused by the expression of TDP-43 with EC50 of 15 uM, α-synuclein or polyglutamine proteins. |
| PC-45271 |
Pramiracetam
Cognitive activator
|
Pramiracetam (CI-879) is a central nervous system stimulant and nootropic agent and PREP (prolyl endopeptidase) inhibitor, shows cognition-restoring and neuroprotective properties. |
| PC-42072 |
BAPTA
Mg2+ chelator
|
BAPTA is a cell-permeant, calcium-specific chelator with high selectivity over Mg2+. |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-26013A |
GPR83 agonist CPD27
GPR83 agonist
|
GPR83 agonist CPD27 is a potent, selective small molecule GPR83 agonist with binding IC50 of 0.1 nM, and EC50 of 0.8 nM for [35S]GTPγS binding to membranes from CHO cells expressing mouse GPR83. |
| PC-28422 |
PF-429242
S1P inhibitor
|
PF-429242 (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-28421 |
CMM-98
OGG1 activator
|
CMM‐98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively. |
| PC-28412 |
F35-303
BEX4-XRCC5 inhibitor
|
F35-303 is a small molecule inhibitor of BEX4-XRCC5 interaction with IC50 of 2.39 uM in Huh6 cells, exhibits binding affinity for XRCC5 with SPR KD of 0.751 uM, suppresses NHEJ repair activity and reduces HB cells cell viability, inhibits cisplatin resistance. |
