| Cat. No. |
Product Name |
Information |
| PC-38711 |
TFF3 inhibitor AMPC
TFF3 inhibitor
|
AMPC is a first-in-class small-molecule inhibitor of the oncogenic functions of trefoil factor 3 (TFF3) that specifically monomerizes dimeric TFF3 to inhibit dimeric TFF3 function, specifically binds to Cys57 of TFF3. |
| PC-38705 |
AF615
CDT1/Geminin inhibitor
|
AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM. |
| PC-38700 |
ALKBH5 inhibitor 20m
ALKBH5 inhibitor
|
ALKBH5 inhibitor 20m is a potent, selective RNA m6A demethylase AlkB homolog 5 (ALKBH5) inhibitor with IC50 of 21 nM. |
| PC-38697 |
PAANIB-1
PAAN/MIF nuclease inhibitor
|
PAANIB-1 is a brain-penetrant PAAN/MIF nuclease inhibitor that prevents neurodegeneration that prevents neurodegeneration induced by α-syn PFF, AAV-α-syn overexpression, or MPTP intoxication in vivo. |
| PC-38675 |
Ninerafaxstat trihydrochloride
|
Ninerafaxstat (CV-8972) is a small molecule compound that promotes glucose oxidation, decreases fatty acid oxidation and improve overall mitochondrial respiration, inhibits the growth and proliferation of cancer cells. |
| PC-38674 |
Ninerafaxstat
|
Ninerafaxstat (CV-8972) is a small molecule compound that promotes glucose oxidation, decreases fatty acid oxidation and improve overall mitochondrial respiration, inhibits the growth and proliferation of cancer cells. |
| PC-38658 |
DS69910557
hPTHR1 antagonist
|
DS69910557 is a highly potent, selective orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist. |
| PC-38655 |
ELOVL1-IN-27
ELOVL1 inhibitor
|
ELOVL1-IN-27 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell). |
| PC-38630 |
PEPCKi
PEPCK inhibitor
|
PEPCKi is a small molecule inhibitor of hosphoenolpyruvate carboxykinase (PEPCK), blocks lactate utilization and impairs tumor growth in colorectal cancer. |
| PC-38614 |
GPR7 antagonist 9i
GPR7 antagonist 9i
|
GPR7 antagonist 9i a highly potent antagonist of NPBWR1 (GPR7) with binding and cAMP IC50 of 0.20 and 0.86 nM for mouse GPR7, respectively. |
| PC-38613 |
GPR7 antagonist 21a
GPR7 antagonist
|
GPR7 antagonist 21a is a highly potent small molecule antagonist of NPBWR1 antagonist with cAMP IC50 of 30 nM, dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding assays. |
| PC-38612 |
ML181
GPR7 antagonist
|
ML181 (CYM50557) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBW1) antagonist probe with IC50 of 270 nM for inhibition of NPW-induced GPR7 activation. |
