| Cat. No. |
Product Name |
Information |
| PC-49175 |
IMU-838
DHODH inhibitor
|
Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49150 |
CBK034026C
NAT2 inhibitor
|
CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity. |
| PC-49117 |
Ansornitinib
|
Ansornitinib is a dual kinase inhibitor and antifibrotic compound for treatment of fibrotic kidney diseases. |
| PC-49095 |
MFI8
Mitofusin inhibitor
|
MFI8 is a small molecule inhibitor of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively decreases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 4.8 uM. |
| PC-49094 |
MASM7
Mitofusin activator
|
MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity. |
| PC-49093 |
NPD389
ME2 inhibitor
|
NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+. |
| PC-49092 |
AS1134900
ME1 inhibitor
|
AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site. |
| PC-49091 |
RKN5755
β-arrestin1 ligand
|
RKN5755 is a small-molecule ligand of β-arrestin1, inhibits the enhanced migration of fibroblasts cocultured with cancer cells by binding to β-arrestin1 and interfering with β-arrestin1-mediated cofilin signaling pathways. |
| PC-49090 |
MCI-100
|
MCI-100 is a small molecule that displays greater potency than sulindac to protect RPE cells against oxidative damage, with lacked significant COX inhibitory activity, MCI-100 is more active than sulindac in protecting cells against oxidative damage. |
| PC-49085 |
ASR352
|
ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells. |
| PC-49043 |
NP-C86
GAS5 inhibitor
|
NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo. |
| PC-49041 |
CD147 inhibitor AC-73
CD147 inhibitor
|
AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells. |
