| Cat. No. |
Product Name |
Information |
| PC-26292 |
STK189682
RNA helicase inhibitor
|
STK189682 is a potent small molecule inhibitor of RNA helicases MDA5, LGP2, and DDX1 with IC50 of 7 uM, 7 uM and 5 uM in ATPase assays. |
| PC-26291 |
UNC11676A
MDA5 inhibitor
|
UNC11676A is a specific small molecule inhibitor of RNA helicase MDA5 with IC50 of 6 uM, >18-fold selective inhibition over LGP2 and DDX1. |
| PC-26275 |
Rebaudioside N
SBK2 agonist
|
Rebaudioside N is a terpenoid glycoside isolated from the leaves of Stevia rebaudiana Bertoni, is a potent SH3 domain-binding kinase 2 (SBK2) agonist, effectively suppresses NLRP3-mediated IL-1β/IL-18 secretion, reduces inflammatory responses, and diminishes atherosclerotic burden. |
| PC-26272 |
CZ-2401
TRIM47-HNF4α inhibitor
|
CZ-2401 is a potent, specific inhibitor of the TRIM47-HNF4α interaction, binds to HNF4α with MST Kd of 2.52 uM, stabilizes HNF4α protein and activates HNF4α transcriptional activity. |
| PC-26260 |
Bufotalin
COL1A1 inhibitor
|
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities, a selective and potent inhibitor of COL1A1-high NSCLC. |
| PC-26246 |
Carbutamide
339-43-5
|
Carbutamide (BZ-55) is Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. |
| PC-26242 |
E8431
DCSTAMP antagonist
|
E8431 (Z2371498431) is a specific small molecule antagonist of fusogenic protein DCSTAMP, disrupts DCSTAMP-RAP1B interaction and inhibits RAP1-RAC1 signaling-mediated cytoskeletal reorganization required for osteoclast maturation and fusion, demonstrats significant osteoclastogenesis inhibition (IC50=0.7758 μM) without cytotoxic effects on mBMMs. |
| PC-26237 |
HF13141-H5
GGCX inhibitor
|
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect. |
| PC-26220 |
Thiostrepton
FOXM1 inhibitor
|
Thiostrepton is a thiazole antibiotic that selectively inhibits FOXM1, also significantly inhibits ETV4 K97-Khib, thereby promoting ferroptosis and suppressing ICC cell migration, invasion, and lung metastasis. |
| PC-26216 |
Furin inhibitor 9
Furin inhibitor
|
Furin inhibitor 9 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 12.4 nM, weakly inhibits the structurally related PC7 with Ki of 278 nM, shows antiviral potency against the furin-dependent H7N7 influenza A strain SC35M. |
| PC-26215 |
Furin inhibitor 27
Furin inhibitor
|
Furin inhibitor 27 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 1.67 nM, also inhibits the structurally related PC7 with Ki of 7.27 nM. |
| PC-26214 |
MI-1851
Furin inhibitor
|
MI-1851 is a highly potent, peptidic mimetic inhibitor of furin with Ki of 10.1 pM, inhibits SARS-CoV-2 replication. |
