| Cat. No. |
Product Name |
Information |
| PC-49232 |
JNJ-1289
Spermine oxidase inhibitor
|
JNJ-1289 (JNJ1289) is a potent, highly selective allosteric inhibitor of human spermine oxidase (hSMOX) with IC50 of 50 nM, inactive against hPAOX and LSD1 (IC50>2,000 nM). |
| PC-49225 |
FOXM1 inhibitor NB-73
FOXM1 inhibitor
|
FOXM1 inhibitor NB-73 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 14 nM and IC50 of 73 nM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49219 |
Kakeimide
GH3 inhibitor
|
Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism. |
| PC-49211 |
TR-107
ClpP activator
|
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
| PC-49203 |
IMP2 inhibitor 4
IGF2BP2 inhibitor
|
IMP2 inhibitor 4 is a small molecule inhibitor of insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2), inhibits IMP2/RNA interaction. |
| PC-49181 |
ZCM-I-1
ROS modulator
|
ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site. |
| PC-49178 |
BDM44768
IDE inhibitor
|
BDM44768 is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE). |
| PC-49176 |
Vidofludimus calcium
DHODH inhibitor
|
Vidofludimus calcium (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49175 |
Vidofludimus
DHODH inhibitor
|
Vidofludimus (IMU-838, 4sc-101) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49154 |
AG17724
Pin1 inhibitor
|
AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in CAFs, leading to efficacious but transient tumor growth inhibition. |
| PC-49150 |
CBK034026C
NAT2 inhibitor
|
CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity. |
| PC-49115 |
NX-13
NLRX1 agonist
|
NX-13 (Amelenodor) is an orally active, gut-restricted NLRX1 agonist, has in situ binding effects on the stability of NLRX1 with EC50 of 58 nM. |
