| Cat. No. |
Product Name |
Information |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-24520 |
GI-Y2
GSDMD inhibitor
|
GI-Y2 (GSDMD inhibitor Y2) is a specific small molecule inhibitor of Gasdermin D (GSDMD), directly interacts with the Arg10 residue of GSDMD (SPR KD=36.0 uM) and reduces the membrane binding of N‐terminal domain (GSDMD‐N). |
| PC-24478 |
CLEC-2 inhibitor MAS9
CLEC-2 inhibitor
|
MAS9 is a specific small molecule inhibitor targeting the C-type lectin-like receptor-2 (CLEC-2)-podoplanin interaction with IC50 of 4.5 uM, inhibits CLEC-2-mediated platelet aggregation. |
| PC-24463 |
FICD inhibitor C22
FICD inhibitor
|
FICD inhibitor C22 is a specific, cell-permeable inhihitor of the AMP transferase FICD, significantly inhibits endogenous FICD-mediated BiP AMPylation (IC50=7.27 uM) while weakly inhibiting BiP deAMPylation. |
| PC-24451 |
Mitochondrial complex I inhibitor C458
CAS 2001090-87-3
|
C458 is nontoxic mitochondrial complex I (mtCI) inhibitor with highly protective against Aβ toxicity, C458 protects MC65 Tet-Off cells (Aβ expressed) with an EC50 of 4.6 nM. |
| PC-24450 |
SMS2 inhibitor Ly93
SMS2 inhibitor
|
SMS2 inhibitor Ly93 is a potent, selective, orally efficacious sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 91 nM, >1000-fold selective over SMS1, demonstrates anti-atherosclerotic activities in vivo. |
| PC-24449 |
SMS2 inhibitor 14l
SMS2 inhibitor
|
SMS2 inhibitor 14l is a highly potent and selective sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 28 nM (sphingomyelin (SM) synthesis), with no activity against SMS1 (IC50=16 uM). |
| PC-24446 |
DCLK1 inhibitor a24
DCLK1 inhibitor
|
DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM. |
| PC-24394 |
BCT1028
BLVRB inhibitor
|
BCT1028 is a potent, selective small molecule Biliverdin IXβ reductase (BLVRB) inhibitor with IC50 of 195 nM (50 uM BLVRB substrate DCPIP). |
| PC-24387 |
TMQ0153
OPA1 inhibitor, Necrosis inducer
|
TMQ0153 (TMQ153) is a tetrahydrobenzimidazole derivative with cytotoxic potential against hematopoietic cancer cell lines, targets mitochondrial dynamics by inhibiting mitochondrial fusion protein optic atrophy 1 (OPA1), inducing metabolic reprogramming, and triggering apoptosis in AML cells. |
