| Cat. No. |
Product Name |
Information |
| PC-49685 |
MPO inhibitor IN-4
MPO inhibitor
|
MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor. |
| PC-49680 |
ART899
DNA Polθ inhibitor
|
ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558. |
| PC-49648 |
FK3453
TSLP inhibitor
|
FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo. |
| PC-49645 |
TH8535
OGG1 inhibitor
|
TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM. |
| PC-49631 |
Brivaracetam
SV2A ligand
|
Brivaracetam (UCB 34714) is a potent, selective synaptic vesicle protein 2A (SV2A) ligand with pKi of 6.5, 20-fold more potent than Levetiracetam (Cat# PC49630), shows anticonvulsant activities in audiogenic mice. |
| PC-49630 |
Levetiracetam
SV2A ligand
|
Levetiracetam (UCB L059) an antiepileptic drug with a unique activity profile in animal models of seizure and epilepsy, binds to (pKi=5.2) and modulates synaptic vesicle protein SV2A. |
| PC-49607 |
NCP26
ProRS inhibitor
|
NCP26 is a potent, ATP-competitive prolyl-tRNA synthetase (ProRS, PRS) inhibitor, inhibits recombinant human ProRS in the presence of 100 μM proline with KD of 0.35 nM in TR-FRET assays. |
| PC-49562 |
F12511
ACAT inhibitor
|
Eflucimibe (F 12511) is a highly potent, selective inhibitor of acyl-CoA: cholesterol acyltransferase ( ACAT/SOAT) with IC50 of 3, 7, and 71 nM in whole cell assays using HepG2, CaCo-2 and THP-1 cell lines, respectively. |
| PC-49561 |
NTE-122
ACAT inhibitor
|
NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM. |
| PC-49557 |
FR054
PGM3 inhibitor
|
FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect. |
| PC-49527 |
SEN177
Gutaminyl cyclase inhibitor
|
SEN177 (SEN-177) is a highly potent human glutaminyl cyclase (hQC) inhibitor Ki value of 20 nM. |
| PC-49516 |
LCRF-0004
Ron kinase inhibitor
|
LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor with IC50 of 50 nM (ELISA), weakly inhibits c-Met with IC50 of 150 nM and does not inhibit VEGFR2. |
