| Cat. No. |
Product Name |
Information |
| PC-72452 |
NCGC00249987
EYA2 inhibitor
|
NCGC00249987 (Compound 9987) is a small-molecule allosteric inhibitor that specifically inhibits the Tyr phosphatase activity of EYA2 with IC50 of 3.1 uM (Eya2 ED), but not other Eya family members. |
| PC-72447 |
SBI-581
TAO3 inhibitor
|
SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily. |
| PC-72440 |
AQX-435
SHIP1 activator
|
AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation. |
| PC-72433 |
GRP-60367
RABV entry inhibitor
|
GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains. |
| PC-72408 |
SACLAC
Acid ceramidase inhibitor
|
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines. |
| PC-72399 |
Panx-1 blocker 15b
Panx-1 blocker
|
Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM. |
| PC-72398 |
NCATS-SM4487
GALK1 inhibitor
|
NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1). |
| PC-72391 |
cis-Epoxysuccinic acid
SUCNR1 (GPR91) agonist
|
cis-Epoxysuccinic acid (cSE) is a synthetic non-metabolite GPR91 agonist with EC50 of 2.7 uM (cAMP levels reducion). |
| PC-72380 |
SUCNR1 inhibitor 20
SUCNR1 (GPR91) antagonist
|
SUCNR1 inhibitor 20 is a potent, selective inhibitor (antagonist) of GPCR SUCNR1 (succinate receptor 1/GPR91) with IC50 of 88 nM. |
| PC-72370 |
Ophiobolin A
Calmodulin inhibitor
|
Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor. |
| PC-72352 |
Calmirasone1
Calmodulin inhibitor
|
Calmirasone1 (Calmirasone 1) is a novel and potent covalent calmodulin (CaM) inhibitor with Kd of 0.87 uM. |
| PC-72348 |
FT113
FASN inhibitor
|
FT113 (FT-113) is a potent inhibitor of fatty acid synthase (FASN) with IC50 of 213 nM (hFASN). |
