| Cat. No. |
Product Name |
Information |
| PC-72575 |
SAFit2
FKBP51 inhibitor
|
SAFit2 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 6 nM, >10,000-fold selectivity over FKBP52. |
| PC-72561 |
GNS561
PPT1 inhibitor
|
GNS561 (Ezurpimtrostat, GNS-561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-72555 |
TET inhibitor C35
TET inhibitor
|
TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome. |
| PC-72551 |
CTPS-IN-T35
CTPS inhibitor
|
CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays. |
| PC-72523 |
Omilancor
LANCL2 agonist
|
Omilancor (BT-11) is a locally-acting, first-in-class, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway. |
| PC-72520 |
BAY-179
Complex I inhibitor
|
BAY-179 (BAY179) is a potent, selective, and species cross-reactive Complex I inhibitor with IC50 of 79 nM. |
| PC-72515 |
ELOVL1-IN-22
ELOVL1 inhibitor
|
ELOVL1-IN-22 is a potent, selective, CNS-penetran inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM. |
| PC-72501 |
JH-RE-06
REV1-REV7 inhibitor
|
JH-RE-06 is a potent REV1-REV7 interface inhibitor (IC50=0.78 uM, Kd=0.42 uM) that disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ, induces REV1 dimerization and blocks POLζ recruitment. |
| PC-72496 |
TH8321
NUDT15 inhibitor
|
TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM. |
| PC-72492 |
SU056
YBX-1 inhibitor
|
SU056 (SU-056) is a specific small molecule that potently inhibits tumor growth and progression via Y box binding protein 1 (YBX-1) inhibition. |
| PC-72476 |
JTE-607
CPSF3 inhibitor
|
JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3). |
| PC-72464 |
PIP4K-IN-a131
PIP4K inhibitor
|
PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells. |
