| Cat. No. |
Product Name |
Information |
| PC-49093 |
NPD389
ME2 inhibitor
|
NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+. |
| PC-49092 |
AS1134900
ME1 inhibitor
|
AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site. |
| PC-49091 |
RKN5755
β-arrestin1 ligand
|
RKN5755 is a small-molecule ligand of β-arrestin1, inhibits the enhanced migration of fibroblasts cocultured with cancer cells by binding to β-arrestin1 and interfering with β-arrestin1-mediated cofilin signaling pathways. |
| PC-49090 |
MCI-100
|
MCI-100 is a small molecule that displays greater potency than sulindac to protect RPE cells against oxidative damage, with lacked significant COX inhibitory activity, MCI-100 is more active than sulindac in protecting cells against oxidative damage. |
| PC-49085 |
ASR352
|
ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells. |
| PC-49043 |
NP-C86
GAS5 modulator
|
NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo. |
| PC-49041 |
CD147 inhibitor AC-73
CD147 inhibitor
|
AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells. |
| PC-49028 |
PSB-CB5
GPR18 antagonist
|
PSB-CB5 is a potent, selective antagonist of GPR18, inhibits GPR18 activation by tetrahydrocannabinol (THC) with IC50 of 279 nM in β-arrestin recruitment assays. |
| PC-49016 |
VSW1198
GGDPS inhibitor
|
VSW1198 is a potent, selective geranylgeranyl diphosphate synthase (GGDPS) inhibitor with IC50 of 45 nM, VSW1198 is highly specific for GGDPS over other enzymes in the isoprenoid biosynthesis (IBP) pathway. |
| PC-49007 |
KBP-066
Amylin/Calcitonin receptor agonist
|
KBP-066 is a potent, selective dual amylin and calcitonin receptor agonist induces an equally potent body weight loss across a broad dose range in obese rats. |
| PC-49001 |
MS21570
GPR171 antagonist
|
MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM). |
| PC-47110 |
MS0015203
GPR171 agonist
|
MS0015203 (MS15203) is a potent, selective small-molecule agonist of neuropeptide receptor GPR171 with binding IC50 of 81 nM (WT GPR171). |
