| Cat. No. |
Product Name |
Information |
| PC-49370 |
GCN2 inhibitor 39
GCN2 inhibitor
|
GCN2 inhibitor 39 is a highly potent and selective, orally active inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 5 nM. |
| PC-49336 |
JBSNF-000028
NNMT inhibitor
|
JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively. |
| PC-49332 |
4-Sulfocalix[8]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49331 |
4-Sulfocalix[6]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49318 |
TK106
SARM1 inhibitor
|
TK106 is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers. |
| PC-49281 |
IL17A inhibitor 10
IL17A inhibitor
|
IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM. |
| PC-49279 |
RUNX1/ETO inhibitor 7.44
RUNX1-ETO inhibitor
|
RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM. |
| PC-49272 |
CRS0540
PolC inhibitor
|
CRS0540 is a potent, selective PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. |
| PC-49271 |
MY-9B
SARM1 inhibitor
|
MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
| PC-49270 |
WX-02-37
SARM1 inhibitor
|
WX-02-37 is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.5 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
| PC-49247 |
DDX3X helicase 86
DDX3X inhibitor
|
DDX3X helicase 87 is a potent, selective and aller inhibitor of DDX3X helicase activity with IC50 of 7 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 6.3 and 0.88 uM, respectively. |
| PC-49245 |
DDX3X helicase 64
DDX3X inhibitor
|
DDX3X helicase 64 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 0.14 μM, shows promising anti-HCV activity, with an EC50 of 0.2 μM and cytotoxicity of 86 μM. |
