| Cat. No. |
Product Name |
Information |
| PC-49735 |
IM156
OXPHOS inhibitor
|
IM156 (HL156A) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin. |
| PC-49721 |
SBT-272
Cardiolipin stablizer
|
SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function. |
| PC-49719 |
EPI-589
Oxidoreductase inhibitor
|
EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases. |
| PC-49692 |
VPS41 inhibitor DMBP
VPS41 inhibitor
|
DMBP is a natural small molecule with preferable anticancer activity, inhibits vacuolar protein sorting-associated protein 41 homolog (VPS41) function, a subunit of the HOPS complex. |
| PC-49677 |
PDS-0330
Claudin-1 inhibitor
|
PDS-0330 (PDS0330) is a first-generation, specific small molecule claudin-1 inhibitor with Kd of 22.9 uM in MST binding assays, impairs the interaction between claudin1 and pSrc/Src and alters survival signaling pathways. |
| PC-49675 |
DS07551382
PTDSS1 inhibitor
|
DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2. |
| PC-49633 |
BI-3231
HSD17B13 inhibitor
|
BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively. |
| PC-49632 |
BI-0955
HSD17B13 inhibitor
|
BI-0955 is an inactive HSD17B13 control compound for BI-3231. |
| PC-49628 |
PKR inhibitor C16
PKR inhibitor
|
PKR inhibitor C16 (GW506033X) is a specific small molecule inhibitor of double-stranded RNA-dependent protein kinase (PKR). |
| PC-49621 |
JYQ-88
PARK7 (DJ-1) inhibitor
|
JYQ-88 is a potent, selective and covalent PARK7 inhibitor with IC50 of 0.13 uM in DiFMUAc assays, 100-fold selectivity over UCHL1 (PARK5, IC50=11.1 uM), covalently modifies the active site Cys106. |
| PC-49591 |
DDIT
Hyaluronan synthase inhibitor
|
DDIT is a potent, non-toxic inhibitor of hyaluronan synthesis via targeting hyaluronan synthase (HAS), significantly suppresses the aggressiveness of triple-negative breast cancer cells grown in tissue culture. |
| PC-49589 |
ARUK2001607
PI5P4Kγ inhibitor
|
ARUK2001607 is a potent, selective and brain penetrant PI5P4Kγ inhibitor with binding KD of 7.1 nM, pIC50 of 7.1 (PI5P4Kγ+). |
