| Cat. No. |
Product Name |
Information |
| PC-27827 |
DD1E5
DDAH1 inhibitor
|
DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation. |
| PC-27821 |
Caffeic acid phenethyl ester
Glyoxalase I inhibitor
|
Caffeic acid phenethyl ester (CAPE) is an active component of propolis and has an antiproliferative property in cancer cell lines via inhibition of NF-κB signaling, downregulation of inhibitor of apoptosis (IAP) family proteins, and modulation of the balance of Bcl-2 family members, inhibits human Glyoxalase I (hGLO I) with IC50 of 7.9 uM. |
| PC-27820 |
CAD-09
Glyoxalase I inhibitor
|
CAD-09 is a caffeic acid ester derivative and potently inhibitor of human Glyoxalase I (GLO I) with IC50 of 1.3 uM (human GLO I), shows significant antiproliferative effect on HL-60 cells. |
| PC-27819 |
FZ581
sEH-P inhibitor
|
FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL). |
| PC-27818 |
NBCn2 inhibitor Cmpd38J
NBCn2 (SLC4A10) inhibitor
|
NBCn2 inhibitor Cmpd38J is a small molecule inhibitor of carbonate transporter NBCn2 (SLC4A10) with IC50 of 20.3 uM. |
| PC-27804 |
BSH-IN-1
BSH inhibitor
|
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. |
| PC-27803 |
BSH inhibitor GR-7
BSH inhibitor
|
BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM. |
| PC-27800 |
SMALS-329
LKB1 activator
|
SMALS-329 is a small-molecule activator of liver kinase B1 (LKB1, STK11) via pseudokinase STE20-related kinase adapter protein (STRAD) with EC50 of 8.5 uM (activation 541%), binds ATP pocket of STRADα to activate LKB1. |
| PC-27779 |
Phoenixin-14
GPR173 ligand
|
Phoenixin-14 (PNX-14) is an endogenous neuropeptide with multiple biological activities and endogenous ligand of GPR173. |
| PC-27766 |
PI5P4Kγ inhibitor n40
PI5P4Kγ inhibitor
|
PI5P4Kγ inhibitor n40 is a potent, selective orthosteric-allosteric dual inhibitor of PI5P4Kγ with Kd of 6.55 nM, has >1000-fold selectivity over PI5P4Kα and PI5P4Kβ. |
| PC-27764 |
IMYX-3
RAB27A inhibitor
|
IMYX-3 is a first-in-class small molecule oral inhibitor of RAB27A, inhibits PMA-activated human neutrophil ROS with IC50 of 0.36 uM in human neutrophils, reduces neutrophil-mediated damage by decreasing ROS, degranulation, and NET formation. |
| PC-27757 |
SLK/STK10-IN-1
SLK/STK10 inhibitor
|
SLK/STK10-IN-1 is a potent, selective dual inhibitor of SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) with IC50 of 1 uM for both in NanoBRET assays in HEK293 cells, shows good kinome-wide selectivity. |
