| Cat. No. |
Product Name |
Information |
| PC-26266 |
CVN14
CD38 inhibitor
|
CVN14 is a potent, selective, uncompetitive and brain-penetrant CD38 inhibitor with IC50 of 19 nM and 2 nM for human and mouse CD38 respectively. |
| PC-26242 |
E8431
DCSTAMP antagonist
|
E8431 (Z2371498431) is a specific small molecule antagonist of fusogenic protein DCSTAMP, disrupts DCSTAMP-RAP1B interaction and inhibits RAP1-RAC1 signaling-mediated cytoskeletal reorganization required for osteoclast maturation and fusion, demonstrats significant osteoclastogenesis inhibition (IC50=0.7758 μM) without cytotoxic effects on mBMMs. |
| PC-26205 |
CN-0928
PCBP2 inhibitor
|
CN-0928 is a specific small molecule inhibitor of poly(C)-binding protein 2 (PCBP2), mitigates AD pathology by inhibiting PCBP2 condensation. |
| PC-26112 |
GSK902056A
PKN3 inhibitor
|
GSK902056A is a highly potent inhibitor of serine/threonine kinase PKN3 with Kdapp of 1 nM, potently engaged PKN3 in cells with IC50 of 79 nM. |
| PC-26109 |
SOD1 lactylation inhibitor ZL-01
SOD1K123la inhibitor
|
SOD1 lactylation inhibitor ZL-01 is a potential specifi inhibitor of csuperoxide dismutase 1 (SOD1) lactylation at lysine 123 (SOD1K123la), effectively reduces the SOD1K123la level and increases SOD1 activity. |
| PC-26108 |
Py-Pip
Neurolysin activator
|
Py-Pip is a nonpeptide small molecule activator of Neurolysin (Nln), enhances the activity of peptidase neurolysin. |
| PC-26087 |
MKV3
Cu+-ATPases inhibitor
|
MKV3 is a specific, first-in-class, broad spectrum inhibitor of Cu-transporting P-type ATPases targeting P1B-type copper ATPases, binds within the Cu+ entry pocket, thereby blocking Cu+ delivery to the intramembranous transport site, dependently decreases Cu+-stimulated ATPase activity with IC50 of 130 nM for Escherichia coli Cu+-ATPase CopA (EcCopA). |
| PC-26075 |
TeGG
UGT1A1 inhibitor
|
1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively. |
| PC-26070 |
APL-4098
GCN2 inhibitor
|
APL-4098 is a potent, selective, ATP-binding site competitive GCN2 inhibitor with Ki of 4.39 nM in TR-FRET assays. |
| PC-26065 |
PSMA-617
PSMA inhibitor
|
PSMA-617 (Vipivotide tetraxetan) is a potent, high affinity prostate-specific membrane antigen (PSMA) inhibitor with Ki of 0.37 nM. |
| PC-26035 |
SecA activator HSI6
SecA activator
|
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states. |
| PC-25996 |
ADAR1i-124
ADAR1 inhibitor
|
ADAR1i-124 is a selective inhibitor of the ADAR1 A-to-I RNA editing activity with in vitro editing IC50 values of 10-30 uM, inhibits the catalytic activities of both ADAR1p150 and ADAR1p110. |
