| Cat. No. |
Product Name |
Information |
| PC-62535 |
SPL-707
SPPL2a inhibitor
|
SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP. |
| PC-62489 |
GAPDS
GAPDH inhibitor, GAPDH segregator
|
GAPDS is a small molecule that targets the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). |
| PC-62473 |
GGTI-286 hydrochloride
GG
|
GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277. |
| PC-62472 |
GGTI-286
GGTase I inhibitor
|
GGTI-286 is a CAAX peptidomimetic, potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277. |
| PC-62471 |
GGTI-2147
GGTase I inhibitor
|
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM). |
| PC-62470 |
GGTI-2133
GGTase I inhibitor
|
GGTI-2133 is a cell-permeable, non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I (IC50=38 nM), displays 40-fold selectivity over FTase. |
| PC-62427 |
IMM-01
|
IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM. |
| PC-62412 |
PDD 00017273
|
PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM. |
| PC-62403 |
CI-976
|
CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM. |
| PC-62387 |
OSMI-1
O-GlcNAc transferase inhibitor
|
OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM. |
| PC-62382 |
RH01687
|
RH01687 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. |
| PC-62379 |
BCI-137
|
BCI-137 is a chemical compound able to compete with Argonaute 2 miRNAs binding, binds to Ago2 with Kd of 126 uM. |
