| Cat. No. |
Product Name |
Information |
| PC-25443 |
UCB1244283
SV2A modulator
|
UCB1244283 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A), selective over SV2B and SV2C, enhances brivaracetam (BRV) binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. |
| PC-25442 |
UCB7361
SV2A modulator
|
UCB7361 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A). |
| PC-25436 |
TREM2 agonist As48
TREM2 agonist
|
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis. |
| PC-25434 |
KDS12025
Hb pseudoperoxidase enhancer
|
KDS12025 is a specific, BBB-permeable small molecule that enhances hemoglobin (Hb) pseudoperoxidase activity 100-fold (EC50=0.04 uM), enabling effective H2O2 decomposition even at extremely low Hb levels. |
| PC-25386 |
Ceranib-2
Ceramidase inhibitor
|
Ceranib-2 (Ceranib2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25385 |
Ceranib-1
Ceramidase inhibitor
|
Ceranib-1 (Ceranib1) is a small molecule ceramidase inhibitor, exhibits antiproliferative effect in SKOV3 cells with IC50 of 4.1 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25362 |
Dracorhodin perchlorate
CD147 inhibitor
|
Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis. |
| PC-25348 |
AV167
ClpP inhibitor
|
AV167 is a potent, small molecule inhibitor of Caseinolytic protease P (ClpP) with IC50 of 1.54 uM. |
| PC-25339 |
CQ3196
RIOK2 inhibitor
|
CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays. |
| PC-25307 |
SyntOFF
Syntenin inhibitor
|
SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin. |
| PC-25281 |
KI-DX-014
DDX21 inhibitor
|
KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity. |
| PC-25280 |
PTC-775
MAPT splicing modulator
|
PTC-775 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 4.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
