| Cat. No. |
Product Name |
Information |
| PC-25612 |
W478
SHMT2 inhibitor
|
W478 is a potent novel serine hydroxymethyltransferase 2 (SHMT2) inhibitor with IC50 of 1.21 uM, binds to SHMT2 with ITC KD of 10.6 uM. |
| PC-25596 |
T2M-010
TREM2 agonist
|
T2M-010 is a potent small molecule binder of Triggering receptor expressed on myeloid cells 2 (TREM2) with MST KD of 0.83 uM, functions as an activator of TREM2 signaling. |
| PC-25586 |
RAGE406R
RAGE inhibitor
|
RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM. |
| PC-25580 |
CIA1 free base
COUP-TFII inhibitor
|
CIA1 free base (COUP-TFII inhibitor A1) is a potent and specific inhibitor of COUP-TFII activity, inhibits COUP-TFII–driven NGFIA reporter expression with IC50 of 3.2 uM, disturbs COUP-TFII binding to FOXA1 to regulate target gene expression. |
| PC-25526 |
MSC778
FEN1 inhibitor
|
MSC778 (MSC-778) is a potent, selective, and orally bioavailable inhibitor of Flap endonuclease 1 (FEN1) with IC50 of 3.0 nM and SPR KD of 2.9 nM, >65-fold selective over closely related RAD2 family members EXO1, GEN1 and XPG. |
| PC-25516 |
iOXCT1
OXCT1 inhibitor
|
iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically. |
| PC-25504 |
DF-003
ALPK1 inhibitor
|
DF-003 (DF003) is a potent, selective and ATP-competitive alpha-kinase 1 (ALPK1) inhibitor with IC50 of 1.5 nM and 16 nM for human ALPK1 and ROSAH disease-causing mutant ALPK1[T237M] respectively. |
| PC-25481 |
W1122
SNX3 inhibitor
|
W1122 is a specific small-molecule inhibitor of Sorting nexin 3 (SNX3). |
| PC-25479 |
SF-153
UHM splicing factor inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
