| Cat. No. |
Product Name |
Information |
| PC-25137 |
GI-Y1
GSDMD inhibitor
|
GSDMD inhibitor Y1 (GI-Y1) is a selective gasdermin D (GSDMD) inhibitor, binds to GSDMD with SPR KD of 7.69 uM, shows cardioprotective effects. |
| PC-25120 |
UNC7437
IPMK inhibitor
|
UNC7437 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 26.2 nM, decreased cellular proliferation and tritiated inositol phosphate levels in human U251-MG glioblastoma cells. |
| PC-25115 |
M6766
ERO1α inhibitor
|
M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM. |
| PC-25050 |
NNZ-2591
Neuroprotective agent
|
Ercanetide (NNZ-2591, NNZ 2591) is an analogue of endogenous diketopiperazine cyclo-glycyl-proline (cyclic GP), shows neuroprotective effect. |
| PC-25037 |
Crovozalpon
Z α1-antitrypsin inhibitor
|
Crovozalpon is a small molecule inhibitor of Z-α1-antitrypsin polymerization. |
| PC-25025 |
Rivasterat
Endothelial dysfunction blocker
|
Rivasterat (CU06-1004, Sac-1004) is a small molecule vascular leakage blocker and endothelial dysfunction blocker, inhibits endothelial hyperpermeability induced by VEGF, histamine and thrombin via stabilization of cortical actin ring and AJ proteins at the cell-cell junction. |
| PC-25014 |
MG-257
Galectin-3/TREM2 inhibitor
|
MG-257 is a small molecule ligand of galectin-3, impedes interaction between TREM2 and galectin-3 with IC50 of 91 nM in TR-FRET assays, attenuates TREM2 signaling. |
| PC-25011 |
YT-II-100
CPSF3 inhibitor
|
YT-II-100 is a novel small molecule inhibitor of Cleavage and Polyadenylation Specific Factor 3 (CPSF3), increases the global abundance of R-loops. |
| PC-25008 |
Veonetinib
Tyrosine kinase inhibitor
|
Veonetinib (Example 3) is an effective inhibitor of tyrosine kinase, exhibits IC50 values of 0.1 μM and 0.4 μM in A549 cells and LOVO cells, respectively. |
| PC-24973 |
Progerinin
Lamin A-Progerin inhibitor
|
Progerinin (SLC-D011) is a specific, small molecule binding inhibitor of lamin A and progerin, reduces progerin expression and improves aging phenotypes in vitro and in vivo HGPS models. |
| PC-24962 |
KL1333
NAD+ modulator, NQO1 substrate
|
KL1333 (Napazimone) is an orally available, small molecule NAD+ modulator, reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. |
| PC-24943 |
LCKLSL hydrochloride
ANXA2 inhibitor
|
LCKLSL hydrochloride (Leu-Cys-Lys-Leu-Ser-Leu) is a potent, specific hexapeptide competitive inhibitor of Annexin A2 (AnxA2), inhibits tissue plasminogen activator (tPA)-binding capacity with IC50 of 11 uM. |
