| Cat. No. |
Product Name |
Information |
| PC-35723 |
OSMI-4
O-GlcNAc transferase inhibitor
|
OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM. |
| PC-35722 |
OGT inhibitor 4a
|
OGT inhibitor 4a (OSMI-4 active form) is a novel potent, selective O-linked N-acetylglucosamine transferase (OGT) inhibitor with Kd of 8 nM, the active form of OSMI-4.. |
| PC-35697 |
DKFZ-251
KLK6 inhibitor
|
DKFZ-251 (DKFZ251) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.13 uM, demonstrates good selectivity for KLK6 compared to other KLKs. |
| PC-35684 |
KAN0438757
PFKFB3 inhibitor
|
KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability. |
| PC-35673 |
WJ460
Myoferlin inhibitor
|
WJ460 (Myoferlin inhibitor WJ460, WJ-460) is a small molecule targeting myoferlin (MYOF), exerts anti-metastatic activity in the nanomolar range in breast cancer cells with IC50 of 43.37 nM in MDA-MB-231 and 36.40 nM in BT549 cells. |
| PC-35660 |
DKFZ-633
KLK6 inhibitor
|
DKFZ-633 (DKFZ633) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.25 uM, demonstrates good selectivity for KLK6 compared to other KLKs. |
| PC-35656 |
BIO922
PICK1 inhibitor
|
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors. |
| PC-35645 |
iST2-1
ST2 inhibitor
|
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively. |
| PC-35607 |
P053
CerS1 inhibitor
|
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6. |
| PC-35588 |
CTPI-2
|
CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo. |
| PC-35583 |
NP161
Thioredoxin 1 inhibitor
|
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM. |
| PC-35582 |
MFN2 agonist B-A l
MFN2 agonist
|
MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM. |
