| Cat. No. |
Product Name |
Information |
| PC-72154 |
CSE inhibitor 43
CSE inhibitor
|
CSE inhibitor 43 is a novel potent, selective, competitive inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 1.2 uM. |
| PC-72138 |
NSC 773097
|
NSC 773097 is a RITA analog that produces hyperselective cytotoxicity while maintaining antitumor efficacy (A498 cell IC50=130 nM). |
| PC-72132 |
BD50265
GPR52 agonist
|
BD50265 (BD 50265) is a potent small-molecule GPR52 agonist. |
| PC-72131 |
BD442618
GPR52 agonist
|
BD442618 (BD 442618) is a potent small-molecule GPR52 agonist. |
| PC-72130 |
WO-459
GPR52 agonist
|
WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53. |
| PC-72129 |
GPR52 antagonist E7
GPR52 antagonist
|
GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM. |
| PC-72127 |
PW0787
GPR52 agonist
|
PW0787 (PW 0787) is a potent, selective, brain-penetrant GPR52 agonist with EC50 of 135 nM in cAMP assays in HEK293 cells. |
| PC-72124 |
AGF347
SHMT2 inhibitor
|
AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM). |
| PC-72110 |
MK-8719
O-GlcNAcase inhibitor
|
MK-8719 (MK8719) is a a highly potent, selective, CNS-penetrable inhibitor of O-GlcNAcase (OGA) with Ki of 7.9 nM (hOGA). |
| PC-72103 |
AM9053
NAAA inhibitor
|
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM). |
| PC-72102 |
ARN19689
NAAA inhibitor
|
ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA). |
| PC-72080 |
GMFBI.1
GMF-β inhibitor
|
GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM. |
