| Cat. No. |
Product Name |
Information |
| PC-28078 |
ABC transporter modulator-3
ABCC6 modulator
|
ABC transporter modulator-3 is a potent, selective positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6 with EC50 of <1 uM, shows high selectivity over ABCB4, ABCA4 P1380L and ACBC2. |
| PC-28077 |
ABC transporter modulator-2
ABCC6 modulator
|
ABC transporter modulator-2 is a potent positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6, ABCB4, and ABCA4 P1380L with EC50 of <1 uM. |
| PC-28076 |
ABC transporter modulator-1
ABCC6 modulator
|
ABC transporter modulator-1 is a potent positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6, ABCB4, and ABCA4 P1380L with EC50 of <1 uM. |
| PC-28075 |
RTY-406
ABCB4/BSEP agonist
|
RTY-406 is a dual-acting ABCB4/BSEP (ATP-binding cassette subfamily B member 4 / bile salt export pump) positive functional modulator (PFM), increases ABCB4 and BSEP protein levels and functional output, thereby increasing biliary phospholipid secretion and bile acid efflux. |
| PC-28065 |
Rusfertide
Hepcidin mimetic, Ferroportin inhibitor
|
Rusfertide (PTG-300) is a peptidic mimetic of hepcidin that binds to ferroportin and decreases iron delivery to bone marrow, reducing the production of red blood cells, shows potential for polycythemia vera and hemochromatosis. |
| PC-28038 |
NSC678917
BAIAP2 inhibitor
|
NSC678917 is a small molecule inhibitor of BAR/IMD domain-containing adaptor protein 2 (BAIAP2, IRSp53) binds to cytoskeletal scaffolding protein BAIAP2 and inhibits MB cell proliferation and migration. |
| PC-28037 |
C273 trihydrochloride
Mitochondrial complex I modulator
|
C273 trihydrochloride is a potent, selective, oral bioavailable, and brain penetratn mitochondrial complex I (mtCI; NADH:ubiquinone oxidoreductase) modulator, protects against Aβ toxicity via modulation of mtCI. |
| PC-28036 |
BDA-41
CBX7 inhibitor
|
BDA-41 is an allosteric P. falciparum aspartate transcarbamoylase (PfATC) inhibitor, also is a polycomb group protein chromobox 7 (CBX7) inhibitor. |
| PC-28035 |
EC134
CBX7 inhibitor
|
EC134 is a potent, cell-active small-molecule inhibitor of CBX7 with IC50 of 34 uM in FP assays, inhibits viability of OCI-AML3 with IC50 of 22 uM. |
| PC-27990 |
SI409-1
DLST K409 succinylation inhibitor
|
SI409-1 is a specific small molecule inhibitor of dihydrolipoamide S-succinyltransferase (DLST) lysine 409 (K409), effectively inhibits DLST K409 succinylation (K409succ). |
| PC-27984 |
YKJ-262
Aster-A/C inhibitor
|
YKJ-262 is a potent, selective inhibitor of cholesterol transfer proteins Aster-A and Aster-C. |
| PC-27983 |
YKJ-86
Aster inhibitor
|
YKJ-86 is a potent, pan-inhibitor of cholesterol transfer proteins Aster-A, -B, and -C, effectively blocks Aster-mediated cholesterol transport in a concentration-dependent manner and completely inhibits cholesterol transport at 10 uM in CHO-K1 cells. |
