| Cat. No. |
Product Name |
Information |
| PC-49511 |
Tryptolinamide
PFK1 inhibitor
|
Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive and F6P-competitive manner (Ki=5.0 uM). |
| PC-49471 |
MO-I-1100
ASPH inhibitor
|
MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells. |
| PC-49460 |
CLOCK inhibitor CLK8
CLOCK inhibitor
|
CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro. |
| PC-49459 |
TH301
CRY2 stabilizer
|
TH301 (TH 301) is a selective small molecule stabilizer of Cryptochrome 2 (CRY2).
KL101 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro. |
| PC-49458 |
KL101
CRY1 stabilizer
|
KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1). |
| PC-49457 |
PGP inhibitor CP1
PGP inhibitor
|
PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells. |
| PC-49456 |
CRY1 destabilizer M47
CRY1 destabilizer
|
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination. |
| PC-49448 |
Eliglustat
GCS inhibitor
|
Eliglustat (GENZ 112638)Eliglustat (GENZ 112638) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays. |
| PC-49442 |
Connexin hemichannel inhibitor D4
Connexin hemichannel inhibitor
|
Connexin hemichannel inhibitor D4 is an orally available small molecule inhibitor of connexin hemichannels (Cx hemichannel). |
| PC-49430 |
SGPL1 inhibitor THI
SGPL1 inhibitor
|
2-acetyl-5-tetrahydroxybutyl imidazole (SGPL1 inhibitor THI) is a small molecule inhibitor of sphingosine-1- phosphate lyase (SGPL1) reduced cell apoptosis in different in vitro huntington's disease (HD) models. |
| PC-49429 |
Larazotide acetate
Zonulin inhibitor
|
Larazotide acetate (AT1001) is a synthetic, competitive octapeptide inhibitor of zonulin, acts as a tight junction regulator to restore intestinal barrier function. |
| PC-49422 |
Transthyretin stabilizer M-23
Transthyretin stabilizer
|
Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume. |
