| Cat. No. |
Product Name |
Information |
| PC-42293 |
EC330
|
EC330 (EC-330, EC 330) is a first-in-class LIF (leukemia inhibitory factor) inhibitor. |
| PC-45623 |
GW-4869
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
|
TPEN (LIN28 inhibitor TPEN) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-22285 |
MS-L6
OXPHOS inhibitor
|
MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS. |
| PC-22262 |
Fatostatin
SREBP inhibitor
|
Fatostatin is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. |
| PC-22255 |
SC26196
D6D inhibitor
|
SC26196 (SC-26196) is a potent, selective delta6 desaturase (Δ6 desaturase, D6D, FADS2) inhibitor with IC50 of 0.2 uM in rat liver microsomal assay. |
| PC-22249 |
PRDX1 inhibitor 15
PRDX1 inhibitor
|
PRDX1 inhibitor 15 is a potent, selective and covalent peroxiredoxin (PRDX1) inhibitor with IC50 of 0.35 uM, covalently binds to Cys-173 of PRDX1 with KD of 0.37 uM, shows antiproliferative potency against colon cancer cells. |
| PC-22248 |
PRDX1 inhibitor H7
PRDX1 inhibitor
|
PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo. |
| PC-22243 |
FeM-1269
Ion mobilizer
|
FeM-1269 is a small molecule ion mobilizer, minimally aggregates and dose-dependently mobilizes iron across lipid bilayers, increases serum iron, transferrin saturation, hemoglobin and hematocrit in mouse model of anemia of inflammation. |
| PC-22240 |
FCW393
Sialyltransferase inhibitor
|
FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis. |
| PC-22222 |
Leflunomide
DHODH inhibitor
|
Leflunomide is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays. |
