| Cat. No. |
Product Name |
Information |
| PC-21894 |
IDE-397
MAT2A inhibitor
|
IDE-397 (GSK-4362676, GSK-676) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts. |
| PC-21877 |
AKST1220
LTA4H inhibitor
|
AKST1220 is a potent, specific leukotriene A4 hydrolase (LTA4H) inhibitor, improves hippocampal dependent memory. |
| PC-21876 |
MIF agonist MIF20
MIF agonist
|
MIF agonist MIF20 is an allosteric small molecule agonist of macrophage migration inhibitory factor (MIF), binds to MIF and increases its affinity for the cognate MIF receptor CD74, increasing the strength of downstream signal transduction. |
| PC-21871 |
FEN1-IN-4
FEN1 inhibitor
|
FEN1-IN-4 is a specific, competitive inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM, binds to atalytic metals and blocks DNA unpairing. |
| PC-21866 |
Them1 inhibitor U1
Them1 inhibitor
|
Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM. |
| PC-21865 |
PCiB-3
Phosphatidylcholine synthesis inhibitor
|
PCiB-3 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 0.4 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2. |
| PC-21864 |
PCiB-2
Phosphatidylcholine synthesis inhibitor
|
PCiB-2 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 2.0 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2, induces mitochondrial division. |
| PC-21863 |
PCiB-1
Phosphatidylcholine synthesis inhibitor
|
PCiB-1 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 7.0 uM, inhibits phosphatidylethanolamine (PE) transport from mitochondria to the endoplasmic reticulum (ER), induces mitochondrial division. |
| PC-21828 |
ZNF207 inhibitor C16
ZNF-207 inhibitor
|
ZNF207 inhibitor C16 is a small molecule inhibitor of Zinc Finger Protein 207 (ZNF207) with binding KD of 67 nM (SPR assays), inhibits glioma cancer cell stemness. |
| PC-21825 |
EC5026
sEH inhibitor
|
EC5026 is a potent, selective orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 0.04 nM, shows potential for the treatment of neuropathic pain. |
| PC-21824 |
AR9281
sEH inhibitor
|
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively. |
| PC-21810 |
Tpm1.8/9-3
Tpm1.8/9 inhibitor
|
Tpm1.8/9-3 (CID 18973468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy. |
