| Cat. No. |
Product Name |
Information |
| PC-38668 |
JHU395
Glutamine antagonist
|
JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM). |
| PC-38667 |
(S)-IBD3540
GCPII inhibitor
|
(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models. |
| PC-38651 |
TLK1 inhibitor J54
TLK1 inhibitor
|
TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide. |
| PC-38631 |
SFI003
SRSF3 inhibitor
|
SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM. |
| PC-38607 |
ML-145
GPR35 inhibitor
|
ML145 (CID-2286812) is a selective GPR35 antagonist with IC50 of 20.1 nM, >1000-fold selectivity over GPR55. |
| PC-38497 |
UNC7467
IP6K inhibitor
|
UNC7467 is a potent, selective inositol hexakisphosphate kinase (IP6K) inhibitor with IC50 values of 8.9 nM (IP6K1), 4.9 nM (IP6K2) and 1320 nM (IP6K3). |
| PC-38478 |
KYP-2047
Prolyl oligopeptidase (PREP) inhibitor
|
KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD. |
| PC-38425 |
Utreloxastat
α-synuclein inhibitor
|
Utreloxastat is a small molecule with potential for suppressing and treating α-synucleinopathies, tauopathies, and other disorders. |
| PC-38422 |
Sirpiglenastat
Glutamine antagonist
|
DRP-104 (Sirpiglenastat) is a novel broad acting glutamine antagonist, has significant anticancer activity by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response. |
| PC-38400 |
Inaxaplin
APOL1 inhibitor
|
Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease. |
| PC-38392 |
Farudodstat
DHODH inhibitor
|
Farudodstat (ASLAN003) is a highly potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 35 nM (human DHODH), significantly inhibits protein synthesis via activation AP-1 transcription, induces cell differentiation of AML cell lines. |
| PC-73413 |
Dexfadrostat
Aldosterone synthase inhibitor
|
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17). |
