| Cat. No. |
Product Name |
Information |
| PC-28436 |
A10P3C
EGLN2 inhibitor
|
A10P3C is a potent, isoform-selective inhibitor of prolyl hydroxylase EGLN2, effectively suppresses breast cancer cell proliferation, migration and invasion, induces G1 cell cycle arrest and cellular senescence through on-target EGLN2 inhibition. |
| PC-28417 |
NGM1
NOS1AP modulator
|
NGM1 is a small molecule NOS1AP modulator of directly binds NOS1AP (CAPON) with SPR KD of 11.9 uM, alters NOS1AP-NOS1 (Nitric oxide synthase, nNOS) proximity, reduces viability in U87 and U251 GBM cells with IC50 values of 12.7 and 17.3 uM, respectively, with no effect on normal human astrocyte viability. |
| PC-28411 |
FOXC1-I4
FOXC1 inhibitor
|
FOXC1-I4 is a small-molecule inhibitor of Forkhead box C1 (FOXC1), binds FOXC1 (SPR KD=2.68 uM) and suppresses FOXC1 transcriptional activity. |
| PC-28384 |
DANA
Neuraminidase inhibitor
|
DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid) is a potent Neuraminidas isoenyzmes (Sialidases, NEU) inhibitor with IC50 of 49, 43, 7.7, and 8.3 uM for NEU1, NEU2, NEU3, and NEU4, respectively, shows anti-influenza virus activity. |
| PC-28362 |
JP4-039
Antioxidant
|
GS-nitroxide (JP4-039) is a mitochondrion-targeted antioxidant nitroxide and mitochondria-targeted reactive species (ROS) scavenger and electron scavenger. |
| PC-28361 |
Gramicidin S
Antibiotic
|
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity, selectively accumulates within microbial cell membranes. |
| PC-28352 |
DMNB-7d
GPR52 agonist
|
DMNB-7d is a photoactivatable GPR52 agonist, shows markedly reduced basal activity in the dark and underwent photoactivation under 405 nM irradiation in cells. |
| PC-28350 |
δ-secretase inhibitor 11a
AEP inhibitor
|
δ-secretase inhibitor 11a (AEP inhibitor CP#11A) is a potent, selective δ-secretase (Asparagine endopeptidase, AEP, Legumain) inhibitor with IC50 of 10 nM, and binding affinity Kd of 5.5 nM. |
| PC-28333 |
Hopantenate calcium
PANK inhibitor
|
Hopantenate Calcium (HoPan) is a pantothenate analogue hopantenate (HoPan) widely used as a modulator of coenzyme A (CoA) levels, inhibits pantothenate kinase (PanK), the first enzyme of CoA biosynthesis, also inhibits inhibits the next enzyme phosphopantothenoylcysteine synthetase (PPCS) in CoA pathway. |
| PC-28329 |
BBP-671
PANK3 activator
|
Claziprotamide (BBP-671) is a potent, brain penetrant small molecule activator of Pantothenate kinase (PanK) with Kd of 97 pM and IC50 of 1.59 nM for PanK3, binds to and activates all PANK isoforms. |
| PC-28328 |
PZ-3022
PANK3 activator
|
PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively. |
| PC-28327 |
VTAC-2
PANK3 activator
|
VTAC-2 is a specific, direct small molecule activator of human PANK3 (Pantothenate kinase 3) with EC50 of 76.5 nM, shows no effect on the catalytic activity of hPANK1 or hPANK2. |
