| Cat. No. |
Product Name |
Information |
| PC-27728 |
UCB-J
SV2A modulator
|
UCB-J is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A) with pIC50 of 8.15 and 7.6 human and rat SV2A respectively. |
| PC-27727 |
ABBV-552
SV2A modulator
|
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A). |
| PC-27712 |
XJ-4-85
PFKL activator
|
XJ-4-85 is a highly selective, covalent, allosteric phosphofructokinase-1 liver type (PFKL) activator with EC50 of 342.3 nM in substrate assays (4h), releases carnitine palmitoyltransferase 2 (CPT2) inhibitor destabilize cancer cell metabolism. |
| PC-27709 |
STK947495
NPM1 oligomerization inhibitor
|
STK947495 is a small-molecule modulator of Nucleophosmin 1 (NPM1) oligomerization, promotes dissociation of NPM1 oligomers, reduces NPM1 oligomerization in both lysate-based split luciferase and biochemical assays. |
| PC-27674 |
TS-002266
TUT4/7 inhibitor
|
TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively. |
| PC-27672 |
FUT8-IN-1
FUT8 inhibitor
|
FUT8-IN-1 is a potent, selective α-1,6-fucosyltransferase (FUT8) inhibitor with KD of 49 nM and IC50 50 uM. |
| PC-27658 |
ADAR1 inhibitor H13
ADAR1 inhibitor
|
ADAR1 inhibitor H13 is potent, orally bioavailable ADAR1 modulator, exhibits potent antiproliferative activity against various cancer cell lines and selectively reduces ADAR1-mediated editing of APOBEC3D in a dose-dependent manner. |
| PC-27639 |
KPSH02
RioK1 inhibitor
|
KPSH02 is a high affinity small molecule inhibitor of Rio Kinase 1 (RioK1) homolog from Archaeoglobus fulgidus (afRioK1) with SPR KD of 39.6 nM. |
| PC-27632 |
TTBK1 inhibitor 62
TTBK1 inhibitor
|
TTBK1 inhibitor 62 is a potent, selective, brain-penetrant ATP-competitive Tau tubulin kinase 1 (TTBK1) inhibitor with IC50 of 0.89 uM, >100-fold selective over TTBK2. |
| PC-27617 |
ABT-E79
PGK1 inhibitor
|
ABT-E79 is a highly potent and selective PGK1 inhibitor, significantly inhibits TNBC cell proliferation. |
| PC-27604 |
OMDM-1
Anandamide uptake inhibitor
|
OMDM-1 is a potent, selective inhibitor of anandamide cellular uptake (ACU) with Ki of 2.4 uM, inhibits anandamide transport. |
| PC-27596 |
Isofagomine
Glycosidase inhibitor
|
Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity. |
